Deficient intracortical inhibition (SICI) during movement preparation after chronic stroke
Deficient intracortical inhibition (SICI) during movement preparation after chronic stroke
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DOI：
10.1212/wnl.0b013e3181a609c5
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发表时间：
2009-05-19
期刊：
影响因子：
9.9
通讯作者：
Gerloff, C.
中科院分区：
文献类型：
--
作者：
Hummel, F. C.;Steven, B.;Gerloff, C.
背景：在健康受试者中，运动准备伴随着运动皮质去抑制。初级运动皮层 (M1) 皮质内抑制功能控制不良可能导致慢性中风后瘫痪手部持续异常运动行为。方法：在这里，我们研究了康复良好的慢性中风患者（n = 14; 63.8 +/- 3.0 岁）的同病 M1 中的 GABA 短皮质内抑制 (SICI)，这些患者正在准备以反应时间范式移动受损的手。结果：主要发现是异常运动准备期间同病灶 M1 中 SICI 持续存在，而年龄匹配的对照组 (n = 14) 则不存在这种情况。此外，相对于对照组，患者组的静息 SICI 有所减少。结论：我们的研究结果证明，慢性中风患者的同侧初级运动皮层中皮质内抑制的动态运动前调节存在缺陷。这种异常可能会导致瘫痪手的运动控制缺陷，从而为慢性中风后开发新型治疗干预措施的框架中的纠正提供了可能的目标。神经病学（R）2009； 72：1766-1772
Background: In healthy subjects, preparation to move is accompanied by motor cortical disinhibition. Poor control of intracortical inhibitory function in the primary motor cortex (M1) might contribute to persistent abnormal motor behavior in the paretic hand after chronic stroke.Methods: Here, we studied GABAergic short intracortical inhibition (SICI) in the ipsilesional M1 in well-recovered chronic stroke patients (n = 14; 63.8 +/- 3.0 years) engaged in preparation to move the impaired hand in a reaction time paradigm.Results: The main finding was an abnormal persistence of SICI in the ipsilesional M1 during movement preparation that was absent in age-matched controls (n = 14). Additionally, resting SICI was reduced in the patient group relative to controls.Conclusions: Our findings document a deficit of dynamic premovement modulation of intracortical inhibition in the ipsilesional primary motor cortex of patients with chronic stroke. This abnormality might contribute to deficits in motor control of the paretic hand, presenting a possible target for correction in the framework of developing novel therapeutic interventions after chronic stroke. Neurology (R) 2009; 72: 1766-1772