From Metabolite to Metabolome: Metabolomics Applications in Plasmodium Research.
From Metabolite to Metabolome: Metabolomics Applications in Plasmodium Research.
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DOI：
10.3389/fmicb.2020.626183
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发表时间：
2020
影响因子：
5.2
通讯作者：
Cao J
中科院分区：
文献类型：
--
作者：
Yu X;Feng G;Zhang Q;Cao J
过去几十年的研究进展极大地改善了研究寄生虫生物学和疾病病因学的代谢组学方法。这改善了对生命阶段期间或在传播到其宿主后的不同代谢需求的调查，并满足了对改进诊断和精确治疗的需求。因此，本文综述了代谢组学在疟疾研究中的进展，包括疟原虫脊椎动物生命周期阶段的代谢图谱，以研究抗疟药物的作用模式和潜在的复杂的宿主-寄生虫相互作用。此外，我们还讨论了目前的局限性，并提出了一些切实可行的建议，以改进方法，从全面的角度推动疟疾代谢组学的进展。
Advances in research over the past few decades have greatly improved metabolomics-based approaches in studying parasite biology and disease etiology. This improves the investigation of varied metabolic requirements during life stages or when following transmission to their hosts, and fulfills the demand for improved diagnostics and precise therapeutics. Therefore, this review highlights the progress of metabolomics in malaria research, including metabolic mapping of Plasmodium vertebrate life cycle stages to investigate antimalarials mode of actions and underlying complex host-parasite interactions. Also, we discuss current limitations as well as make several practical suggestions for methodological improvements which could drive metabolomics progress for malaria from a comprehensive perspective.
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影响因子：
3
作者：
Ghosh, Soumita;Sengupta, Arjun;Sonawat, Haripalsingh M.
通讯作者：
Sonawat, Haripalsingh M.
影响因子：
13.1
作者：
Dunn, WB;Ellis, DI
通讯作者：
Ellis, DI
影响因子：
64.8
作者：
Gamo, Francisco-Javier;Sanz, Laura M.;Garcia-Bustos, Jose F.
通讯作者：
Garcia-Bustos, Jose F.
影响因子：
4.6
作者：
Brown, Audrey C.;Moore, Christopher C.;Guler, Jennifer L.
通讯作者：
Guler, Jennifer L.
影响因子：
4.1
作者：
Gardinassi, Luiz Gustavo;Cordy, Regina Joice;Li, Shuzhao
通讯作者：
Li, Shuzhao