Prognostic impact of c-KIT mutations in core binding factor acute myeloid leukemia
Prognostic impact of c-KIT mutations in core binding factor acute myeloid leukemia
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DOI：
10.1016/j.leukres.2011.06.003
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发表时间：
2011-10-01
影响因子：
2.7
通讯作者：
Park, Chan-Jeoung
中科院分区：
文献类型：
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作者：
Park, Sang Hyuk;Chi, Hyun-Sook;Park, Chan-Jeoung
本研究旨在确定c-KIT突变对核心结合因子急性髓性白血病（CBF AML）患者预后的影响。本研究纳入1999年1月至2010年5月峨山医疗中心诊断为CBF AML的116例患者。我们使用熔化曲线分析和直接测序方法来确认c-KIT突变在第17外显子（mutKIT17）和第8外显子（mutKIT8）。在116例患者中，36例（31%）发现mutKIT17, 7例（6%）发现mutKIT8。在t（8;21）患者中，mutKIT17患者的预后明显差于没有突变的患者。这种差异仅限于成年人。在inv患者中（16），c-KIT突变对预后没有影响。因此，推荐在成年CBF AML患者中分析mutKIT17（8; 21）作为预测预后的手段。(C) 2011 Elsevier Ltd.版权所有。
This study sought to define the prognostic impact of c-KIT mutations in core binding factor acute myeloid leukemia (CBF AML) patients. A total of 116 patients diagnosed as CBF AML in Asan Medical Center from January 1999 to May 2010 were enrolled in this study. We applied melting curve analyses and direct sequencing methods to confirm c-KIT mutations in exon 17 (mutKIT17) and exon 8 (mutKIT8). Of the total 116 patients, mutKIT17 were found in 36 (31%) and mutKIT8 were found in 7 (6%). In patients with t(8;21), prognosis was significantly poorer in those with mutKIT17 compared to those without the mutation. This difference was limited to adults. In patients with inv(16), there was no prognostic impact of c-KIT mutations. Therefore, an analysis of mutKIT17 in adult CBF AML patients with t(8; 21) is recommended as a means to predict prognosis. (C) 2011 Elsevier Ltd. All rights reserved.