Considerable time from the onset of plaque rupture and/or thrombi until the onset of acute myocardial infarction in humans - Coronary angiographic findings within 1 week before the onset of infarction
Considerable time from the onset of plaque rupture and/or thrombi until the onset of acute myocardial infarction in humans - Coronary angiographic findings within 1 week before the onset of infarction
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DOI：
10.1161/01.cir.102.17.2063
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发表时间：
2000-10-24
期刊：
影响因子：
37.8
通讯作者：
Fujiwara, H
中科院分区：
文献类型：
--
作者：
Ojio, S;Takatsu, H;Fujiwara, H
背景：人们一直认为，斑块破裂或轻度狭窄血管内皮损伤后发生的斑块血栓和出血会突然阻塞管腔并导致急性心肌梗死（AMI），然而，我们的假设是血栓和出血可能不会突然阻塞管腔。方法与结果：研究组20例AMI前1周（3+/-3天）行冠状动脉造影的患者和对照组20例AMI前6 ~ 18个月（282+/-49天）行冠状动脉造影的患者，AMI前3天的梗死相关冠状动脉段（IRCS）表现为明显狭窄50%（发生率95%，直径狭窄71+/-12%）和Ambroseⅱ型偏心病变（多处不规则）；这是斑块破裂和/或血栓的一个指标（60% [70%]），AMI前1年的特征是轻度狭窄
Background-It has been thought that the thrombi and bleeding in plaques that occur after plaque rupture or endothelial damage from vessels with mild stenosis suddenly occlude the lumen and cause acute myocardial infarction (AMI), However, our hypothesis is that thrombi and bleeding may not suddenly occlude the lumen.Methods and Results-The study group consisted of 20 patients who had coronary angiograms performed within 1 week (3+/-3 days) before AMI and 20 control patients who had coronary angiograms performed 6 to 18 months (282+/-49 days) before AMI, The features of infarct-related coronary segments (IRCS) at 3 days before AMI were the presence of a significant stenosis of >50% (95% in incidence and 71+/-12% diameter stenosis) and Ambrose's type II eccentric lesions (plus multiple irregularities), an indicator of plaque rupture and/or thrombi (60% [70%]), and the features at 1 year before AMI were mild stenosis of