Resveratrol suppresses colitis and colon cancer associated with colitis.
Resveratrol suppresses colitis and colon cancer associated with colitis.
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DOI：
10.1158/1940-6207.capr-09-0117
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发表时间：
2010-04
期刊：
影响因子：
--
通讯作者：
Hofseth LJ
中科院分区：
文献类型：
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作者：
Cui X;Jin Y;Hofseth AB;Pena E;Habiger J;Chumanevich A;Poudyal D;Nagarkatti M;Nagarkatti PS;Singh UP;Hofseth LJ
白藜芦醇是一种天然存在的多酚，具有多种有益健康的作用，包括抗炎，心脏和癌症保护活动。它被认为是预防和治疗慢性炎症和自身免疫性疾病的最有前途的天然分子之一。溃疡性结肠炎（UC）是一种与结肠癌高风险相关的特发性慢性结肠炎性疾病。在这里，我们使用了葡聚糖硫酸钠（DSS）结肠炎小鼠模型，其类似于人类UC病理学。白藜芦醇混合食物以剂量依赖性方式改善DSS诱导的小鼠结肠炎。白藜芦醇显著改善炎症评分，下调肠系膜淋巴结和前浆层中中性粒细胞的百分比，并调节表达肿瘤坏死因子-α和干扰素γ的CD 3 + T细胞。炎症和炎症应激的标志物（p53和p53-磷酸丝氨酸15）也被白藜芦醇下调。由于慢性结肠炎导致结肠癌的风险，我们进行了实验，以确定白藜芦醇的化学预防特性。肿瘤发生率从用氧化偶氮甲烷（AOM）+ DSS处理的小鼠中的80%降低到AOM + DSS +白藜芦醇（300 p. p.m.）治疗小鼠。白藜芦醇治疗也降低了肿瘤的多样性。AOM + DSS处理的小鼠每只动物有2.4 ± 0.7个肿瘤，而AOM + DSS + 300 p. p.m.白藜芦醇处理的小鼠每只动物有0.2 ± 0.13个肿瘤。目前的研究表明，白藜芦醇是一种有用的，无毒的补充和替代策略，以减轻结肠炎和潜在的结肠癌与结肠炎。
Resveratrol is a naturally occurring polyphenol that exhibits pleiotropic health beneficial effects including anti-inflammatory, cardio- and cancer-protective activities. It is recognized as one of the more promising natural molecules in the prevention and treatment of chronic inflammatory and autoimmune disorders. Ulcerative Colitis (UC) is an idiopathic, chronic inflammatory disease of the colon associated with a high colon cancer risk. Here, we used a Dextran Sulfate Sodium (DSS) mouse model of colitis, which resembles human UC pathology. Resveratrol mixed in food ameliorates DSS-induced colitis in mice in a dose-dependent manner. Resveratrol significantly improves inflammation score, down regulates the percentage of neutrophils in the mesenteric lymph nodes and lamina propiria, and modulates CD3+ T cells that express tumor necrosis factor-alpha and interferon gamma. Markers of inflammation and inflammatory stress (p53 and p53-Phospho-Serine 15), are also down regulated by resveratrol. Since chronic colitis drives colon cancer risk, we carried out experiments to determine the chemopreventive properties of resveratrol. Tumor incidence is reduced from 80% in mice treated with Azoxymethane (AOM) + DSS to 20% in AOM + DSS + Resveratrol (300 p.p.m.) treated mice. Tumor multiplicity also decreased with resveratrol treatment. AOM + DSS treated mice had 2.4 ± 0.7 tumors per animal compared with AOM + DSS + 300 p.p.m. resveratrol, which had 0.2 ± 0.13 tumors per animal. The current study indicates that resveratrol is a useful, non-toxic complementary and alternative strategy to abate colitis and potentially colon cancer associated with colitis.