Morphometric features of the craniocervical junction region in dogs with suspected Chiari-like malformation determined by combined use of magnetic resonance imaging and computed tomography
Morphometric features of the craniocervical junction region in dogs with suspected Chiari-like malformation determined by combined use of magnetic resonance imaging and computed tomography
复制标题
DOI：
10.2460/ajvr.73.1.105
复制
发表时间：
2012-01-01
影响因子：
1
通讯作者：
Akerman, Meredith B.
中科院分区：
文献类型：
--
作者：
Marino, Dominic J.;Loughin, Catherine A.;Akerman, Meredith B.
目的客观描述216只Cavalier King Charles Spaniels（CKCS）犬和58只非CKCS犬疑似Chian样畸形（CLM）的颅颈交界区的形态测量学特征，并确定这些特征与该区域其他畸形的存在之间的关系。由于怀疑CLM而评估的患者的头部和颅颈交界区的磁共振和计算机断层扫描图像被评估为小脑压迫（CC），C1-C2关节处的腹侧脊髓压迫（髓扭结）和C1-C2关节处的背侧脊髓压迫（背侧压迫）。计算每只犬这3个部位的压迫指数。进行了多元Logistic回归分析，以确定是否品种（CKCS与非CKCS）和压缩指数值与其他cranioceradium交界处abnormality.Results-All 274只狗CC的存在;髓扭结被确定在187（68.2%）和背侧压缩被确定在104（38.0%）。76只（277%）犬发现枕叶重叠（AOO）。犬种（CKCS vs非CKCS）和CC指数值是AOO的唯一显著预测因素。CKCS有几乎5倍的AOO的风险下降，与非CKCS狗相比，AOO的风险几乎增加了一倍，每增加10% CC index.Conclusions和临床相关性的解剖异常负责CC AOO在相当大的比例怀疑有CLM的狗。CC指数值可用于帮助区分犬颅颈交界处异常的亚型。(Am J Vet Res 2012;73：105-111）
Objective To objectively describe morphometric features of the craniocervical junction region of Cavalier King Charles Spaniels (CKCSs) and non-CKCS dogs with suspected Chian-like malformation (CLM) and identify associations between these features and the presence of other malformations in this region.Animals-216 CKCSs and 58 non-CKCS dogs.Procedures-Magnetic resonance and computed tomographic images of the head and craniocervical junction region of patients evaluated because of suspected CLM were assessed for cerebellar compression (CC), ventral spinal cord compression at the C1-C2 articulation (medullary kinking), and dorsal spinal cord compression at the C1-C2 articulation (dorsal compression). A compression index was calculated for each of these 3 locations in each dog. Multiple logistic regression analysis was performed to determine whether breed (CKCS vs non-CKCS) and compression index values were associated with the presence of other craniocervical junction abnormalities.Results-All 274 dogs had CC; medullary kinking was identified in 187 (68.2%) and dorsal compression was identified in 104 (38.0%). Atlantooccipital overlapping (AOO) was identified in 76 (277%) dogs. Breed of dog (CKCS vs non-CKCS) and value of CC index were the only significant predictors of AOO. The CKCSs had an almost 5-fold decrease in risk of AOO, compared with the non-CKCS dogs, and the risk of AOO nearly doubled for every 10% increase in CC index.Conclusions and Clinical Relevance-The anatomic abnormality responsible for CC was AOO in a substantial percentage of dogs suspected to have CLM. The CC index value may be used to help differentiate subtypes of craniocervical junction abnormalities in dogs. (Am J Vet Res 2012;73:105-111)