Ex vivo programming of antigen-presenting B lymphocytes: considerations on DNA uptake and cell activation.
Ex vivo programming of antigen-presenting B lymphocytes: considerations on DNA uptake and cell activation.
复制标题
抗原呈递 B 淋巴细胞的离体编程：DNA 摄取和细胞激活的考虑。
DOI：
10.1080/08830180600743131
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Zanetti,Maurizio
中科院分区：
文献类型：
--
作者：
Wheeler,Matthew;Cortez-Gonzalez,Xotchil;Frazzi,Raffaele;Zanetti,Maurizio
DNA疫苗中使用的质粒不仅是一种抗原源，而且具有重要的佐剂作用。本文就细胞如何内化DNA，以及内化DNA如何激活免疫反应通路的研究进展作一综述。我们还评论了B细胞在这两个过程中的作用。
Plasmids used in DNA vaccination not only serve as a source of antigen, but also have an important adjuvant effect. This review focuses on recent advancements made in understanding how cells internalize DNA, and how internalized DNA activates immune response pathways. We also comment on the role of B cells in both of these processes.