The retrovirus RNA trafficking granule: from birth to maturity.
The retrovirus RNA trafficking granule: from birth to maturity.
复制标题
逆转录病毒RNA贩运颗粒：从出生到成熟。
DOI：
10.1186/1742-4690-3-18
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发表时间：
2006-03-17
期刊：
影响因子：
3.3
通讯作者：
Mouland, Andrew J.
中科院分区：
文献类型：
--
作者：
Cochrane, Alan W.;T McNally, Mark;Mouland, Andrew J.
RNA 生命中的转录后事件，包括 RNA 加工、运输、翻译和代谢，其特征是多个核糖核蛋白 (RNP) 复合物的受调节组装。在每个步骤中，RNA 结合蛋白都会发生接合和脱离，直到 RNA 到达最终目的地。对于逆转录病毒基因组RNA，最终目的地是衣壳。大量研究提供了有关这些过程的重要信息，并作为逆转录病毒 RNA 细胞内命运研究的基础。逆转录病毒 RNA 与细胞 mRNA 类似，但其加工过程受到多个顺式作用序列和许多反式作用蛋白的活性更严格的调节。这篇综述描述了逆转录病毒RNA在从细胞核开始的成熟过程中遇到的病毒和细胞伙伴，重点关注重要事件，包括剪接、3'末端加工、RNA从细胞核到细胞质的运输，以及最终导致其分化为子代病毒体的机制。
Post-transcriptional events in the life of an RNA including RNA processing, transport, translation and metabolism are characterized by the regulated assembly of multiple ribonucleoprotein (RNP) complexes. At each of these steps, there is the engagement and disengagement of RNA-binding proteins until the RNA reaches its final destination. For retroviral genomic RNA, the final destination is the capsid. Numerous studies have provided crucial information about these processes and serve as the basis for studies on the intracellular fate of retroviral RNA. Retroviral RNAs are like cellular mRNAs but their processing is more tightly regulated by multiple cis-acting sequences and the activities of many trans-acting proteins. This review describes the viral and cellular partners that retroviral RNA encounters during its maturation that begins in the nucleus, focusing on important events including splicing, 3' end-processing, RNA trafficking from the nucleus to the cytoplasm and finally, mechanisms that lead to its compartmentalization into progeny virions.
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