Natural products as promising drug candidates for the treatment of Alzheimer's disease: molecular mechanism aspect.
Natural products as promising drug candidates for the treatment of Alzheimer's disease: molecular mechanism aspect.
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DOI：
10.2174/1570159x11311040005
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发表时间：
2013-07
影响因子：
5.3
通讯作者：
Khodagholi F
中科院分区：
文献类型：
--
作者：
Ansari N;Khodagholi F
阿尔茨海默病(AD)是迄今为止最常见的神经退行性疾病，没有根治性或预防性的治疗方法。AD的组织病理学特征包括β-淀粉样斑块的沉积和神经原纤维缠结的形成。对该病的病理学研究已在发病机制和潜在的治疗靶点方面取得了重要发现。许多细胞变化，包括氧化应激，钙离子稳态的破坏，炎症，代谢紊乱，以及未折叠/错误折叠蛋白的积累，都可以导致AD细胞的程序性死亡。尽管进行了密集的研究，但只有五种批准的药物可用于治疗AD。因此，有必要研究替代疗法。近年来，在医学上使用天然产品和烹饪草药变得越来越流行。几种具有神经保护作用的天然物质已被广泛研究。这些化合物大多具有显着的抗氧化性能，主要通过清除自由基类发挥作用。其中一些通过直接影响淀粉样蛋白的发生和编程的细胞死亡途径来增加细胞存活率和改善认知。对这些天然产物及其作用机制的进一步研究，同时使用新的药物设计和给药技术，使我们能够提供常规药物的补充。本文就天然产物对A-β具有潜在的神经保护作用及其作用机制作一综述。
Alzheimer’s disease (AD) is the most common neurodegenerative disorder to date, with no curative or preventive therapy. Histopathological hallmarks of AD include deposition of β-amyloid plaques and formation of neurofibrillary tangles. Extent studies on pathology of the disease have made important discoveries regarding mechanism of disease and potential therapeutic targets. Many cellular changes including oxidative stress, disruption of Ca2+ homeostasis, inflammation, metabolic disturbances, and accumulation of unfolded/misfolded proteins can lead to programmed cell death in AD. Despite intensive research, only five approved drugs are available for the management of AD. Hence, there is a need to look at alternative therapies. Use of natural products and culinary herbs in medicine has gained popularity in recent years. Several natural substances with neuroprotective effects have been widely studied. Most of these compounds have remarkable antioxidant properties and act mainly by scavenging free radical species. Some of them increase cell survival and improve cognition by directly affecting amyloidogenesis and programmed cell death pathways. Further studies on these natural products and their mechanism of action, parallel with the use of novel pharmaceutical drug design and delivery techniques, enable us to offer an addition to conventional medicine. This review discussed some natural products with potential neuroprotective properties against Aβ with respect to their mechanism of action.