Photodynamic antimicrobial chemotherapy using zinc phthalocyanine derivatives in treatment of bacterial skin infection
Photodynamic antimicrobial chemotherapy using zinc phthalocyanine derivatives in treatment of bacterial skin infection
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DOI：
10.1117/1.jbo.21.1.018001
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发表时间：
2016-01-01
影响因子：
3.5
通讯作者：
Huang, Mingdong
中科院分区：
文献类型：
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作者：
Chen, Zhuo;Zhang, Yaxin;Huang, Mingdong
光动力学抗菌化疗（PACT）是一种有效的杀灭细菌细胞的方法，针对日益严重的细菌多重耐药问题。我们在此报道了使用锌酞菁衍生物，五赖氨酸β-羰基酞菁锌（ZnPc-（Lys）（5））对涉及皮肤感染的细菌的PACT效果。与其阴离子ZnPc对应物相比，ZnPc-（Lys）（5）在体外和局部感染的动物模型中显示出增强的抗菌效力。同时，观察到ZnPc-（Lys）（5）在伤口愈合期间显著减少伤口皮肤血流量，表明抗炎活性。本研究为PACT治疗细菌性皮肤感染的机制提供了新的见解。(C)2016年，美国光电仪器工程师学会（SPIE）
Photodynamic antimicrobial chemotherapy (PACT) is an effective method for killing bacterial cells in view of the increasing problem of multiantibiotic resistance. We herein reported the PACT effect on bacteria involved in skin infections using a zinc phthalocyanine derivative, pentalysine beta-carbonylphthalocyanine zinc (ZnPc-(Lys)(5)). Compared with its anionic ZnPc counterpart, ZnPc-(Lys)(5) showed an enhanced antibacterial efficacy in vitro and in an animal model of localized infection. Meanwhile, ZnPc-(Lys)(5) was observed to significantly reduce the wound skin blood flow during wound healing, indicating an anti-inflammation activity. This study provides new insight on the mechanisms of PACT in bacterial skin infection. (C) 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)