Influence of Plasma Cortisol and Other Laboratory Parameters on Nonalcoholic Fatty Liver Disease
Influence of Plasma Cortisol and Other Laboratory Parameters on Nonalcoholic Fatty Liver Disease
复制标题
DOI：
10.1055/s-0034-1389982
复制
发表时间：
2015-06-01
影响因子：
2.2
通讯作者：
Flechtner-Mors, M.
中科院分区：
文献类型：
--
作者：
Hubel, J. M.;Schmidt, S. A.;Flechtner-Mors, M.
本研究的目的是分析血浆皮质醇浓度与非酒精性脂肪性肝病(NAFLD)的关系。共有1326名受试者(年龄18-65岁)在以人群为基础的随机抽样流行病学研究的背景下进行了检查。记录了662名女性和664名男性的病史和人体测量数据。此外，还进行了实验室检查，并通过超声检查估计了肝脏的脂肪浓度。血浆皮质醇平均浓度女性为260.4+/-156.8nmol/L，男性为295.8+/-161.2nmol/L。非酒精性脂肪肝在女性中的发病率为17.7%，在男性中的发病率为35.1%。血浆皮质醇浓度与NAFLD的存在无关。NAFLD与年龄、体重指数(BMI)、腰臀比(WHR)、丙氨酸氨基转移酶(ALT)和甘油三酯呈正相关。本研究未能建立血浆皮质醇浓度与NAFLD之间的任何联系。
The objective of the present study was to analyse the association between the plasma cortisol concentration and nonalcoholic fatty liver disease (NAFLD). A total of 1326 subjects (age 18-65 years) were examined in the context of an epidemiological study of a population-based random sample. Medical history and anthropometric data of 662 women and 664 men were documented. In addition, laboratory examinations were performed and the fat concentration of the liver was estimated by ultrasound examination. Mean cortisol concentration in plasma was 260.4 +/- 156.8nmol/l for women and 295.8 +/- 161.2nmol/l for men. NAFLD was identified in 17.7% in women and 35.1% in men. Plasma cortisol concentration showed no association with the existence of NAFLD. NAFLD correlated positive with age, body-mass index (BMI), waist-to-hip-ratio (WHR), alanine aminotransferase (ALT), and triglycerides. The present study failed to establish any association of plasma cortisol concentrations and NAFLD.