Protective autoimmunity functions by intracranial immunosurveillance to support the mind: The missing link between health and disease
Protective autoimmunity functions by intracranial immunosurveillance to support the mind: The missing link between health and disease
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DOI：
10.1038/mp.2010.31
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发表时间：
2010-04
影响因子：
11
通讯作者：
M. Schwartz;R. Shechter
中科院分区：
文献类型：
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作者：
M. Schwartz;R. Shechter
循环免疫细胞支持海马神经发生、空间记忆、脑源性神经营养因子的表达和应激恢复。然而，考虑到中枢神经系统（CNS）的免疫特权状态，假定这些细胞被排除在健康脑之外。然而，很明显，中枢神经系统是由白细胞不断调查，虽然他们的功能仍然是一个谜。将这种常规的白细胞运输与循环T细胞在大脑可塑性中的功能结合起来，我们在这里提出，中枢神经系统免疫监视是大脑功能的一个组成部分。选择的自我识别白细胞在解剖学上限制在大脑的边界和液体（脑脊液）中，不仅支持大脑的活动，而且还控制了这些细胞的潜在攻击性。因此，大脑的“特权”是它在自己的控制下获得了一个私人的外周免疫生态位，这支持了大脑的功能。免疫功能障碍可能是健康和患病的大脑之间缺失的一环。
Circulating immune cells support hippocampal neurogenesis, spatial memory, expression of brain-derived neurotrophic factor, and resilience to stress. Nevertheless, considering the immune privileged status of the central nervous system (CNS), such cells were assumed to be excluded from the healthy brain. It is evident, however, that the CNS is continuously surveyed by leukocytes, though their function is still a mystery. Coupling this routine leukocyte trafficking with the function attributed to circulating T cells in brain plasticity led us to propose here that CNS immunosurveillance is an integral part of the functioning brain. Anatomical restriction of selected self-recognizing leukocytes to the brain's borders and fluids (cerebrospinal fluid) not only supports the brain's activity, but also controls the potential aggressiveness of such cells. Accordingly, the brain's ‘privilege’is its acquisition of a private peripheral immunological niche under its own control, which supports brain function. Immune malfunction may comprise a missing link between a healthy and diseased mind.