Slow early growers have more muscle in relation to adult activity: evidence from Cebu, Philippines.

Slow early growers have more muscle in relation to adult activity: evidence from Cebu, Philippines.
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缓慢的早期生长者在成年活动中拥有更多的肌肉:来自菲律宾宿雾的证据。

DOI:
10.1038/ejcn.2015.18
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发表时间:
2015
影响因子:
4.7
通讯作者:
Kuzawa,CW
Kuzawa,CW
中科院分区:
医学3区
文献类型:
--
作者:
Workman,M;McDade,TW;Adair,LS;Kuzawa,CW

文献摘要

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Results:SMM (mean±sd) was 20.8±3.9 kg (men) and 13.6±3.4 kg (women). Faster early weight gain predicted a higher adult SMM. After adjustment for height and lifestyle factors, strongest associations with SMM were found for 6–12 months growth in men (β= 0.17, P= 0.001) and for birth weight in women (β= 0.14, P= 0.001). Individuals who had grown slowly displayed greater SMM in association with adult weightlifting, basketball playing and physically demanding forms of employment (men) or household chores (women).Conclusions:These results suggest heightened sensitivity of activity-induced muscle hypertrophy among the adults who were born light or who gained weight slowly as infants. Future research should test this finding by comparing responses of muscle mass to an intervention in slow vs fast early growers. Findings suggest that adults who display a reduced SMM following suboptimal early growth may be good candidates for new anti-diabetes interventions that promote muscle-building activities.