Humanized Mouse Models for Evaluation of PSC Immunogenicity.
Humanized Mouse Models for Evaluation of PSC Immunogenicity.
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DOI：
10.1002/cpsc.113
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发表时间：
2020-06
影响因子：
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通讯作者：
Jack Hermsen;Matthew E Brown
中科院分区：
文献类型：
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作者：
Jack Hermsen;Matthew E Brown
新的人类多能干细胞（hPSC）衍生疗法正以越来越快的速度进入临床试验阶段。除了确保这些疗法正常发挥作用外，迫切需要研究人类对这些细胞产物的免疫反应。强大的同种异体（或自体）免疫反应可以迅速消除其他有希望的细胞疗法，即使在免疫抑制的患者中也是如此。在未来几年，再生医学领域的研究人员将需要利用大量的体外和体内试验和模型来评估和更好地了解hPSC的免疫原性。人源化小鼠模型（植入功能性人类免疫细胞类型的小鼠）是研究hPSC治疗的适应性免疫反应机制的重要研究工具。本文概述了与hPSC免疫原性研究相关的人源化小鼠模型，并探讨了研究人员在研究中寻求利用这些强大模型的中心考虑因素。©2020 Wiley期刊有限责任公司
New human pluripotent stem cell (hPSC)-derived therapies are advancing to clinical trials at an increasingly rapid pace. In addition to ensuring that the therapies function properly, there is a critical need to investigate the human immune response to these cell products. A robust allogeneic (or autologous) immune response could swiftly eliminate an otherwise promising cell therapy, even in immunosuppressed patients. In coming years, researchers in the regenerative medicine field will need to utilize a number of in vitro and in vivo assays and models to evaluate and better understand hPSC immunogenicity. Humanized mouse models-mice engrafted with functional human immune cell types-are an important research tool for investigating the mechanisms of the adaptive immune response to hPSC therapies. This article provides an overview of humanized mouse models relevant to the study of hPSC immunogenicity and explores central considerations for investigators seeking to utilize these powerful models in their research. © 2020 Wiley Periodicals LLC.