Interaction Between Brain Histamine and Serotonin, Norepinephrine, and Dopamine Systems: In Vivo Microdialysis and Electrophysiology Study
Interaction Between Brain Histamine and Serotonin, Norepinephrine, and Dopamine Systems: In Vivo Microdialysis and Electrophysiology Study
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DOI：
10.1007/s12031-015-0536-3
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发表时间：
2015-06-01
影响因子：
3.1
通讯作者：
Dremencov, Eliyahu
中科院分区：
文献类型：
--
作者：
Flik, Gunnar;Folgering, Joost H. A.;Dremencov, Eliyahu
脑内单胺（5-羟色胺、去甲肾上腺素、多巴胺和组胺）在情绪、认知、病理生理和精神障碍的治疗中起着重要作用。血清素，去甲肾上腺素和多巴胺之间的相互作用在许多作品中进行了研究;然而，组胺系统受到的关注较少。本研究的目的是研究组胺和其他单胺类之间的相互作用，使用在体内微透析和电生理。结果发现，组胺-3受体的反向激动剂，硫代哌丁胺，增加腹侧被盖区多巴胺神经元的放电活动。选择性组胺-3受体激动剂immepip可逆转噻哌丁胺对多巴胺神经元放电活动的刺激。immepip或硫代哌丁胺不会减弱5-羟色胺和去甲肾上腺素神经元的放电率。硫代哌丁胺强烈和显着增加细胞外浓度的血清素，去甲肾上腺素，多巴胺在大鼠前额叶皮层和轻微增加去甲肾上腺素和多巴胺水平在结节乳头核的下丘脑。可以得出结论，组胺刺激大脑中的血清素、去甲肾上腺素和多巴胺传递。多巴胺神经元放电的调节是组胺和其他单胺类物质之间功能性相互作用的关键因素。组胺-3受体拮抗剂，由于其潜在的能力，刺激单胺神经传递，可能是有益的精神疾病的治疗。
Brain monoamines (serotonin, norepinephrine, dopamine, and histamine) play an important role in emotions, cognition, and pathophysiology and treatment of mental disorders. The interactions between serotonin, norepinephrine, and dopamine were studied in numerous works; however, histamine systemreceived less attention. The aim of this study was to investigate the interactions between histamine and other monoamines, using in vivo microdialysis and electrophysiology. It was found that the inverse agonist of histamine-3 receptors, thioperamide, increased the firing activity of dopamine neurons in the ventral tegmental area. Selective agonist of histamine-3 receptors, immepip, reversed thiperamide-induced stimulation of firing activity of dopamine neurons. The firing rates of serotonin and norpeinephrine neurons were not attenuated by immepip or thioperamide. Thioperamide robustly and significantly increased extracellular concentrations of serotonin, norepinephrine, and dopamine in the rat prefrontal cortex and slightly increased norepinephrine and dopamine levels in the tuberomammillary nucleus of the hypothalamus. It can be concluded that histamine stimulates serotonin, norepinephrine, and dopamine transmission in the brain. Modulation of firing of dopamine neurons is a key element in functional interactions between histamine and other monoamines. Antagonists of histamine-3 receptors, because of their potential ability to stimulate monoamine neurotransmission, might be beneficial in the treatment of mental disorders.