Chemogenomics with protein secondary-structure mimetics.
Chemogenomics with protein secondary-structure mimetics.
复制标题
具有蛋白质二级结构模拟物的化学基因组学。
DOI：
10.1007/978-1-60761-274-2_5
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Che,Ye
中科院分区：
文献类型：
--
作者：
Marshall,GarlandR;Kuster,DanielJ;Che,Ye
During molecular recognition of proteins in biological systems, helices, reverse turns, and β-sheets are dominant motifs. Often there are therapeutic reasons for blocking such recognition sites, and significant progress has been made by medicinal chemists in the design and synthesis of semirigid molecular scaffolds on which to display amino acid side chains. The basic premise is that preorganization of the competing ligand enhances the binding affinity and potential selectivity of the inhibitor. In this chapter, current progress in these efforts is reviewed.
