Memory trace replay: the shaping of memory consolidation by neuromodulation.
Memory trace replay: the shaping of memory consolidation by neuromodulation.
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DOI：
10.1016/j.tins.2015.07.004
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发表时间：
2015-09
影响因子：
15.9
通讯作者：
Mellor JR
中科院分区：
文献类型：
--
作者：
Atherton LA;Dupret D;Mellor JR
记忆痕迹重放是由挥之不去的兴奋性和突触可塑性造成的。重放机制的平衡可以通过神经调节来确定。乙酰胆碱的释放可以塑造尖锐波涟漪重播的方向。多巴胺的释放可以决定重播哪些细胞集合。人们认为，在网络层面上，对地点和事件的记忆的巩固依赖于代表离散地点和空间轨迹的空间调谐神经元放电模式的重放。这种情况发生在睡眠或休息期间发生的尖波纹波事件 (SWR) 期间的海马-内嗅回路中。在这里，我们回顾了细胞集合内挥之不去的位置细胞兴奋性和行为诱导的突触可塑性的理论模型，以解释哪些序列或位置被重播。我们进一步提供了关于不同行为状态下胆碱能波动如何影响重放方向以及响应新奇或奖励的多巴胺能释放如何调节重放哪些细胞组件的新见解。
Memory trace replay results from lingering excitability and synaptic plasticity. The balance of replay mechanisms may be determined by neuromodulation. Acetylcholine release can shape the direction of replay in sharp wave ripples. Dopamine release can dictate which cell assemblies are replayed. The consolidation of memories for places and events is thought to rely, at the network level, on the replay of spatially tuned neuronal firing patterns representing discrete places and spatial trajectories. This occurs in the hippocampal-entorhinal circuit during sharp wave ripple events (SWRs) that occur during sleep or rest. Here, we review theoretical models of lingering place cell excitability and behaviorally induced synaptic plasticity within cell assemblies to explain which sequences or places are replayed. We further provide new insights into how fluctuations in cholinergic tone during different behavioral states might shape the direction of replay and how dopaminergic release in response to novelty or reward can modulate which cell assemblies are replayed.