Quantitative multiparametric MRI assessment of glioma response to radiotherapy in a rat model
Quantitative multiparametric MRI assessment of glioma response to radiotherapy in a rat model
复制标题
大鼠模型中神经胶质瘤对放疗反应的定量多参数 MRI 评估
DOI：
10.1093/neuonc/not245
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发表时间：
2014-06-01
期刊：
影响因子：
15.9
通讯作者：
Zhou, Jinyuan
中科院分区：
文献类型：
--
作者：
Hong, Xiaohua;Liu, Li;Zhou, Jinyuan
结构 MRI 无法准确测量肿瘤对治疗的反应，使神经胶质瘤患者的护理管理变得复杂。本研究的目的是评估几种非侵入性功能和分子 MRI 生物标志物在评估神经胶质瘤对放射治疗的反应方面的潜力。使用小动物放射研究平台（40 或 20 Gy）对 14 只 U87 荷瘤大鼠进行照射，并用 6 只大鼠作为对照。 MRI 在 4.7 T 动物扫描仪上、放射治疗前以及放射后 3、6、9 和 14 天进行。对肿瘤的图像特征以及肿瘤体积和动物存活率进行了定量比较。结构 MRI 显示，所有受辐射的肿瘤在辐射后的最初几天内仍然增大。与放射前相比，除放射后第 3 天外，肿瘤的表观扩散系数 (ADC) 值在放射后（40 和 20 Gy）显着增加。放射后肿瘤血流量显着减少（40 和 20 Gy），但相对血流量（肿瘤与对侧）在放射后的大多数时间点没有显示出显着变化。肿瘤的酰胺质子转移加权 (APTw) 信号在放射后的所有时间点 (40 Gy) 以及放射后第 9 天 (20 Gy) 均显着下降。血流和 APTw 图显示的肿瘤特征与钆增强 T-1 加权图像上看到的相似。肿瘤 ADC、血流和 APTw 都是有用的成像生物标志物，可用于预测神经胶质瘤对放疗的反应。 APTw 信号最有希望用于该模型中的早期反应评估。
The inability of structural MRI to accurately measure tumor response to therapy complicates care management for patients with gliomas. The purpose of this study was to assess the potential of several noninvasive functional and molecular MRI biomarkers for the assessment of glioma response to radiotherapy.Fourteen U87 tumor-bearing rats were irradiated using a small-animal radiation research platform (40 or 20 Gy), and 6 rats were used as controls. MRI was performed on a 4.7 T animal scanner, preradiation treatment, as well as at 3, 6, 9, and 14 days postradiation. Image features of the tumors, as well as tumor volumes and animal survival, were quantitatively compared.Structural MRI showed that all irradiated tumors still grew in size during the initial days postradiation. The apparent diffusion coefficient (ADC) values of tumors increased significantly postradiation (40 and 20 Gy), except at day 3 postradiation, compared with preradiation. The tumor blood flow decreased significantly postradiation (40 and 20 Gy), but the relative blood flow (tumor vs contralateral) did not show a significant change at most time points postradiation. The amide proton transfer weighted (APTw) signals of the tumor decreased significantly at all time points postradiation (40 Gy), and also at day 9 postradiation (20 Gy). The blood flow and APTw maps demonstrated tumor features that were similar to those seen on gadolinium-enhanced T-1-weighted images.Tumor ADC, blood flow, and APTw were all useful imaging biomarkers by which to predict glioma response to radiotherapy. The APTw signal was most promising for early response assessment in this model.