Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus
Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus
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DOI：
10.1136/ard.2007.075424
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发表时间：
2008-04-01
影响因子：
27.4
通讯作者：
Harley, J. B.
中科院分区：
文献类型：
--
作者：
Sawalha, A. H.;Kaufman, K. M.;Harley, J. B.
目的：系统性红斑狼疮（SLE）的病因学尚不完全清楚。遗传和环境因素都与该病的发病机制有关。在此，我们描述了SLE和白细胞介素（IL）-21基因多态性之间的遗传关联。IL-21对B细胞分化为浆细胞的影响，其对树突状细胞成熟和T细胞反应的影响，使IL-21一个有吸引力的候选基因SLE.Methods：在IL-21基因的三个单核苷酸多态性（SNPs）进行基因分型，共2636人（1318例和1318对照年龄，性别和种族相匹配）。结果：我们发现IL-21基因内的两个SNP与SLE有遗传关联（rs 907715：chi（2）= 11.55，p
Objective: The aetiology of systemic lupus erythematosus (SLE) is incompletely understood. Both genetic and environmental factors are implicated in the pathogenesis of the disease. Herein, we describe genetic association between SLE and polymorphisms in the interleukin (IL)-21 gene. The reported effect of IL-21 on B-cell differentiation into plasma cells and its effect on dendritic cell maturation and T-cell responses make IL-21 an attractive candidate gene for SLE.Methods: Three single nucleotide polymorphisms (SNPs) in the IL-21 gene were genotyped in a total of 2636 individuals (1318 cases and 1318 controls matched for age, sex and race). Population-based case-control association analyses were performed.Results: We found a genetic association with SLE and two SNPs located within the IL-21 gene (rs907715: chi(2) = 11.55, p