Comparative cost assessment of the Kato-Katz and FLOTAC techniques for soil-transmitted helminth diagnosis in epidemiological surveys.
Comparative cost assessment of the Kato-Katz and FLOTAC techniques for soil-transmitted helminth diagnosis in epidemiological surveys.
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DOI：
10.1186/1756-3305-3-71
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发表时间：
2010-08-14
影响因子：
3.2
通讯作者：
Utzinger J
中科院分区：
文献类型：
--
作者：
Speich B;Knopp S;Mohammed KA;Khamis IS;Rinaldi L;Cringoli G;Rollinson D;Utzinger J
Kato-Katz技术广泛用于流行病学调查中土壤传播蠕虫病的诊断，被认为是一种廉价的方法。FLOTAC技术显示出更高的灵敏度，用于诊断光强度土壤传播的蠕虫感染，但据报道是更复杂和昂贵的。我们评估了在坦桑尼亚桑给巴尔进行的流行病学调查中使用Kato-Katz和FLOTAC技术收集、处理和显微镜检查粪便样本的相关成本。我们测量了在现场采集单个粪便标本的时间，转移到实验室，使用Kato-Katz和FLOTAC技术的标准方案进行准备和显微镜检查。确定了卫生工作者的工资、预期寿命和材料的资产成本以及基础设施成本。计算了单次或两次Kato-Katz厚涂片和FLOTAC双重或双重技术的平均成本。收集粪便标本和进行一次或两次Kato-Katz厚涂片或FLOTAC双重或双重技术所需的平均时间分别为20 min和34 sec（20：34 min）、27：21 min、28：14 min和36：44 min。单次和两次Kato-Katz厚涂片的总费用分别为1.73美元和2.06美元，FLOTAC双重和双重技术分别为2.35美元和2.83美元。薪金对这两种方法的总费用影响最大。在流行病学调查中，使用Kato-Katz或FLOTAC方法进行土源性蠕虫诊断的时间和费用相当可观。我们的研究结果可以帮助指导医疗保健决策者和科学家进行流行病学调查，驱虫药疗效试验和控制干预措施的监测的预算规划和资金。
The Kato-Katz technique is widely used for the diagnosis of soil-transmitted helminthiasis in epidemiological surveys and is believed to be an inexpensive method. The FLOTAC technique shows a higher sensitivity for the diagnosis of light-intensity soil-transmitted helminth infections but is reported to be more complex and expensive. We assessed the costs related to the collection, processing and microscopic examination of stool samples using the Kato-Katz and FLOTAC techniques in an epidemiological survey carried out in Zanzibar, Tanzania. We measured the time for the collection of a single stool specimen in the field, transfer to a laboratory, preparation and microscopic examination using standard protocols for the Kato-Katz and FLOTAC techniques. Salaries of health workers, life expectancy and asset costs of materials, and infrastructure costs were determined. The average cost for a single or duplicate Kato-Katz thick smears and the FLOTAC dual or double technique were calculated. The average time needed to collect a stool specimen and perform a single or duplicate Kato-Katz thick smears or the FLOTAC dual or double technique was 20 min and 34 sec (20:34 min), 27:21 min, 28:14 min and 36:44 min, respectively. The total costs for a single and duplicate Kato-Katz thick smears were US$ 1.73 and US$ 2.06, respectively, and for the FLOTAC double and dual technique US$ 2.35 and US$ 2.83, respectively. Salaries impacted most on the total costs of either method. The time and cost for soil-transmitted helminth diagnosis using either the Kato-Katz or FLOTAC method in epidemiological surveys are considerable. Our results can help to guide healthcare decision makers and scientists in budget planning and funding for epidemiological surveys, anthelminthic drug efficacy trials and monitoring of control interventions.