Cortical activity influences geniculocortical spike efficacy in the macaque monkey
Cortical activity influences geniculocortical spike efficacy in the macaque monkey
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DOI：
10.3389/neuro.07/003.2007
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发表时间：
2007-01-01
影响因子：
3.5
通讯作者：
Usrey, W. Martin
中科院分区：
文献类型：
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作者：
Briggs, Farran;Usrey, W. Martin
丘脑-皮层信息传递是一个受突触前和突触后机制共同影响的动态过程。在这项研究中，我们记录了从外侧膝状体核（LGN）接收直接输入的皮层神经元的单单位反应，以解决先前的皮层活动模式是否影响LGN输入驱动皮层反应的能力的问题。通过检查LGN电诱发尖峰到达之前的持续活动，我们确定了一些预测阈上通信的活动模式。也就是说，当皮层神经元的活动水平增加到30- 40 Hz和/或它们的活动在γ频段显示出随着功率增加的节律模式（30 ms间隔）时，它们更可能对LGN刺激作出反应。皮质神经元也更有可能响应LGN刺激时，他们的活动增加30-40毫秒前的刺激，这表明γ活动的阶段也有助于膝皮质通信。基于这些结果，我们得出的结论是，正在进行的活动在皮层是不是随机的，而是有组织的方式，可以影响动态的丘脑皮质通信。
Thalamocortical communication is a dynamic process influenced by both presynaptic and postsynaptic mechanisms. In this study, we recorded single-unit responses from cortical neurons that received direct input from the lateral geniculate nucleus (LGN) to address the question of whether prior patterns of cortical activity affect the ability of LGN inputs to drive cortical responses. By examining the ongoing activity that preceded the arrival of electrically evoked spikes from the LGN, we identified a number of activity patterns that were predictive of suprathreshold communication. Namely, cortical neurons were more likely to respond to LGN stimulation when their activity levels increased to 30-40Hzand/or their activity displayed rhythmic patterns (30 ms intervals) with increased power in the gamma frequency band. Cortical neurons were also more likely to respond to LGN stimulation when their activity increased 30-40 ms prior to stimulation, suggesting that the phase of gamma activity also contributes to geniculocortical communication. Based on these results, we conclude that ongoing activity in the cortex is not random, but rather organized in a manner that can influence the dynamics of thalamocortical communication.