Urinary excretion of ecgonine methyl ester, a major metabolite of cocaine in humans.
Urinary excretion of ecgonine methyl ester, a major metabolite of cocaine in humans.
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DOI：
10.1093/jat/8.1.23
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发表时间：
1984
影响因子：
2.5
通讯作者：
J. Ambre;M. Fischman;T. Ruo
中科院分区：
文献类型：
--
作者：
J. Ambre;M. Fischman;T. Ruo
在这项研究中，可卡因，benzoylecgonine，并在尿中的ecgonine甲酯排泄量进行了测量后，静脉内和鼻内给药可卡因在16，32，48，和96毫克剂量的健康可卡因用户。通过气相色谱/质谱法分析了爱贡碱甲酯和可卡因。通过免疫测定法（EMIT）和液相色谱法测定苯甲酰芽子碱。尿中的芽子碱甲酯占可卡因剂量的26 - 60%。芽子碱甲酯的消除半衰期为4.2小时，而苯甲酰芽子碱为5.1小时。这些结果表明，芽子碱甲酯占大多数以前未确定的可卡因的尿代谢产物。芽子碱甲酯排泄的时间过程是这样的，其检测可以取代苯甲酰芽子碱检测作为可卡因使用的标志物。
In this study, cocaine, benzoylecgonine, and ecgonine methyl ester excretion in urine was measured after intravenous and intranasal administration of cocaine at 16, 32, 48, and 96 mg doses to healthy cocaine users. Ecgonine methyl ester and cocaine were analyzed by gas chromatography/mass spectrometry. Benzoylecgonine was measured by immunoassay (EMIT) and liquid chromatography. Urinary ecgonine methyl ester accounted for 26 to 60% of the cocaine dose. Ecgonine methyl ester had an elimination halflife of 4.2 hr, compared with 5.1 hr for benzoylecgonine. These results indicate that ecgonine methyl ester accounts for most of the previously unidentified urinary metabolic products of cocaine. The time course of ecgonine methyl ester excretion is such that its detection can substitute for benzoylecgonine detection as a marker of cocaine use.