Genetic Factors in Intervertebral Disc Degeneration.
Genetic Factors in Intervertebral Disc Degeneration.
复制标题
椎间盘变性中的遗传因素。
DOI：
10.1016/j.gendis.2016.04.005
复制
发表时间：
2016-09
期刊：
影响因子：
6.8
通讯作者：
Wang, Jinxi
中科院分区：
文献类型：
--
作者：
Feng, Yi;Egan, Brian;Wang, Jinxi
腰痛是人类致残的主要原因之一，在世界范围内给人类社会带来了巨大的经济负担。在导致腰痛的诸多因素中，椎间盘退变（IDD）是最常见的疾病，也是干预的目标。IDD的病因是复杂的，其机制仍未完全了解。衰老、脊柱畸形与疾病、脊柱损伤、遗传等因素参与了IDD的发病机制。在这篇综述中，我们将重点介绍与人类缺乏症相关的最有前途和被广泛研究的遗传因素的最新研究进展。许多遗传缺陷与椎间盘（IVD）内的结构和功能变化有关，这可能损害椎间盘的力学特性和代谢活动。这些遗传和蛋白质组学研究已经开始揭示IDD的分子基础，表明遗传因素是IDD发病和发展的重要因素。通过不断提高我们对IDD分子机制的理解，未来将有可能对这种致残疾病进行具体的早期诊断和更有效的治疗。
Low back pain (LBP) is a major cause of disability and imposes huge economic burdens on human society worldwide. Among many factors responsible for LBP, intervertebral disc degeneration (IDD) is the most common disorder and is a target for intervention. The etiology of IDD is complex and its mechanism is still not completely understood. Many factors such as aging, spine deformities and diseases, spine injuries, and genetic factors are involved in the pathogenesis of IDD. In this review, we will focus on the recent advances in studies on the most promising and extensively examined genetic factors associated with IDD in humans. A number of genetic defects have been correlated with structural and functional changes within the intervertebral disc (IVD), which may compromise the disc's mechanical properties and metabolic activities. These genetic and proteomic studies have begun to shed light on the molecular basis of IDD, suggesting that genetic factors are important contributors to the onset and progression of IDD. By continuing to improve our understanding of the molecular mechanisms of IDD, specific early diagnosis and more effective treatments for this disabling disease will be possible in the future.