Phosphatidylethanol is Superior to Carbohydrate-Deficient Transferrin and -Glutamyltransferase as an Alcohol Marker and is a Reliable Estimate of Alcohol Consumption Level
Phosphatidylethanol is Superior to Carbohydrate-Deficient Transferrin and -Glutamyltransferase as an Alcohol Marker and is a Reliable Estimate of Alcohol Consumption Level
复制标题
DOI：
10.1111/acer.12883
复制
发表时间：
2015-11-01
影响因子：
3.2
通讯作者：
Isaksson, Anders
中科院分区：
文献类型：
--
作者：
Walther, Lisa;de Bejczy, Andrea;Isaksson, Anders
背景在临床实践和研究情况下，获得关于患者饮酒的可靠信息是非常重要的。这项研究的目的是调查酒精生物标志物的相关性（磷脂酰乙醇[PEth]，碳水化合物缺乏转铁蛋白[CDT]，-谷氨酰转移酶，天冬氨酸转氨酶，和丙氨酸氨基转移酶）回顾性以及基于日记的酒精自我报告，并检查是否有可能将生物标志物结果与更精确的酒精消费水平相关联。酒精依赖患者被纳入酒精依赖药物治疗的随机、安慰剂对照临床试验，其中115人（76名男性和39名女性）完成了研究。在基线时收集回顾性饮酒数据，并在研究期间使用酒精日记。结果PEth r（s）= 0. 56，CDT r（s）= 0. 35，与回顾性饮酒数据（PEth r（s）= 0. 23，CDT r（s）= 0. 22）相比，PEth r（s）和CDT r（s）与日记中记录的饮酒量有更好的相关性。在2种酒精生物标志物PEth和CDT之间观察到甚至更高的相关性（r（s）=0.63）。在所有的消费水平，PEth的所有生物标志物studyed.ConclusionsPEth的敏感性最高的生物标志物与自我报告的酒精消费量的最佳相关性。PEth上级优于CDT，因为其灵敏度显著更高，但也因为其与自我报告的相关性更密切。PEth值可以转化为酒精消费的近似水平，PEth似乎是比自我报告更可靠的酒精消费指标。
BackgroundIn clinical practice as well as research situations, it is of great importance to get reliable information about a patient's alcohol consumption. The aim of the study was to investigate the correlation of alcohol biomarkers (phosphatidylethanol [PEth], carbohydrate-deficient transferrin [CDT], -glutamyltransferase, aspartate aminotransferase, and alanine aminotransferase) to retrospective as well as diary-based alcohol self-reports and to examine whether it is possible to correlate a biomarker result to a more precise level of alcohol consumption.MethodsOne hundred and sixty alcohol-dependent patients were included in a randomized, placebo-controlled clinical trial of pharmacotherapy for alcohol dependence, of which 115 (76 men and 39 women) completed the study. Retrospective alcohol consumption data were collected at baseline, and alcohol diaries were used during the study. Blood samples for determination of alcohol biomarkers were collected on 5 occasions during the study.ResultsPEth and CDT showed a better correlation with alcohol consumption documented in the diary (PEth r(s)=0.56 and CDT r(s)=0.35) than with retrospective consumption data (PEth r(s)=0.23 and CDT r(s)=0.22). An even higher correlation (r(s)=0.63) was seen between the 2 alcohol biomarkers PEth and CDT. At all consumption levels, PEth had the highest sensitivity of all biomarkers studied.ConclusionsPEth was the biomarker with the best correlation to self-reported alcohol consumption. PEth was superior to CDT owing to its substantially higher sensitivity but also due to its closer correlation to self-report. PEth values can be translated into an approximate level of alcohol consumption and PEth appears to be a more reliable measure of alcohol consumption than self-reports.