Efficacy of elemental diet on prevention for chemoradiotherapy-induced oral mucositis in patients with oral squamous cell carcinoma
Efficacy of elemental diet on prevention for chemoradiotherapy-induced oral mucositis in patients with oral squamous cell carcinoma
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DOI：
10.1007/s00520-015-2866-7
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发表时间：
2016-02-01
影响因子：
3.1
通讯作者：
Ueyama, Yoshiya
中科院分区：
文献类型：
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作者：
Harada, Koji;Ferdous, Tarannum;Ueyama, Yoshiya
放射或放化疗引起的口腔粘膜炎会损害口腔鳞状细胞癌（OSCC）患者的生活质量。本研究旨在评估元素饮食 (ED)、ElentalA (R) 对 OSCC 患者放疗或放化疗引起的粘膜炎的预防作用。本回顾性研究纳入了 74 名接受放疗 (60-70 Gy) 联合/不联合化疗 [S-1、顺铂 (CDDP)、CDDP 加 S-1] 的患者； 37 名患者在治疗期间接受了 ElentalA (R)（ElentalA (R) 组），37 名患者未接受治疗（对照组）。通过多变量逻辑回归分析确定与缓解口腔粘膜炎相关的因素。根据治疗方案比较 ElentalA (R) 组和对照组的放化疗完成率。还进行了组间营养状况的比较。多变量分析表明，服用ElentalA（R）和不联合化疗（单独放疗）是与口腔粘膜炎程度相关的显着因素，即与对照组相比，大多数服用ElentalA（R）的患者的粘膜炎程度较低。 ElentalA (R) 与放化疗（无中断）完成率的显着提高相关。 ElentalA (R) 组与对照组在放疗前后体重或血清总蛋白和白蛋白水平的平均变化无显着差异。本研究表明 ElentalA (R) 可有效改善 OSCC 患者因放疗引起的口腔粘膜炎。 ElentalA (R) 还与（化疗）放疗完成率的提高相关。
Oral mucositis induced by radiation or chemoradiation can compromise the quality of life of oral squamous cell carcinoma (OSCC) patients. The present study was designed to evaluate the preventive effects of elemental diet (ED), ElentalA (R), on radiotherapy- or chemoradiotherapy-induced mucositis in OSCC patients.Seventy-four patients who underwent radiation (60-70 Gy) with/without chemotherapy [S-1, cisplatin (CDDP), CDDP plus S-1] were enrolled in this retrospective study; 37 had received ElentalA (R) during treatment (ElentalA (R) group) and 37 had not (control group). Factors related to alleviation of oral mucositis were identified by multivariate logistic regression analysis. Rates of completion of chemoradiation treatments were compared between ElentalA (R) and control groups according to the treatment regimen. The comparison of the nutritional status between groups was also performed.Multivariate analysis indicated that the administration of ElentalA (R) and no combined chemotherapy (radiation alone) were significant factors associated with the degree of oral mucositis, i.e., most of the patients who consumed ElentalA (R) suffered from a lower degree of mucositis compared to the control group. ElentalA (R) was associated with a significantly improved rate of completion of chemoradiation (no interruption). There was no significant difference between ElentalA (R) group and control group in terms of mean change of body weight or total protein and albumin levels in blood serum before and after (chemo)radiation.The present study indicates that ElentalA (R) is effective for ameliorating oral mucositis induced by (chemo)radiation in OSCC patients. ElentalA (R) was also associated with improved completion rates of (chemo)radiotherapy.