A single gene encodes multiple neuropeptides mediating a stereotyped behavior
A single gene encodes multiple neuropeptides mediating a stereotyped behavior
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单个基因编码介导刻板行为的多种神经肽
DOI：
10.1016/0092-8674(83)90492-0
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发表时间：
1983
期刊：
影响因子：
64.5
通讯作者：
R. Axel
中科院分区：
文献类型：
--
作者：
R. Scheller;J. F. Jackson;L. McAllister;B. Rothman;E. Mayeri;R. Axel
Aaprosia的产卵特征是由几种神经活性肽介导的刻板行为阵列。我们已经测序了两个基因编码的A和B肽被认为是启动产卵过程，以及一个基因编码的产卵激素（ELH），直接介导的行为阵列。这三个基因共享90%的序列同源性，是一个小的多基因家族的代表。每个基因编码蛋白质前体，其中活性肽侧接内部切割位点，提供产生多个小肽的潜力。这三个基因中的每一个都由与A或B肽以及ELH同源的序列组成。虽然这些基因具有显著的核苷酸同源性，但它们已经分化，使得不同的成员基因在不同组织中表达功能相关但不重叠的神经活性肽组。
Egg laying in Aplysia is characterized by a stereotyped behavioral array which is mediated by several neuroactive peptides. We have sequenced two genes encoding the A and B peptides thought to initiate the egg-laying process, as well as a gene encoding egg-laying hormone (ELH) which directly mediates the behavioral array. The three genes share 90% sequence homology and are representatives of a small multigene family. Each gene encodes a protein precursor in which the active peptides are flanked by internal cleavage sites providing the potential to generate multiple small peptides. Each of the three genes consists of sequences homologous to A or B peptide as well as ELH. Although these genes share significant nucleotide homology, they have diverged such that different member genes express functionally related but nonoverlapping sets of neuroactive peptides in different tissues.