Risk of leukemia associated with the first course of cancer treatment: an analysis of the Surveillance, Epidemiology, and End Results Program experience.
Risk of leukemia associated with the first course of cancer treatment: an analysis of the Surveillance, Epidemiology, and End Results Program experience.
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与癌症治疗第一个疗程相关的白血病风险：对监测、流行病学和最终结果计划经验的分析。
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发表时间：
1984
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影响因子：
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通讯作者：
J. Young
中科院分区：
文献类型：
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作者：
R. Curtis;B. Hankey;M. Myers;J. Young
美国国家癌症研究所的监测、流行病学和最终结果项目对1973-80年间确诊的44万多名患者（平均随访1.91年）进行了白血病风险与第一疗程癌症治疗相关的评估。虽然第一个疗程的报告可能不完整，但在70,674名已知接受初始化疗的患者中，发生了34例急性非淋巴细胞白血病（ANLL），而预期为7.6例[相对危险度(RR) = 4.5, 95%可信区间(Cl) = 3.1-6.3]。在乳腺癌（RR = 8.1）、卵巢癌（RR = 22.2）和多发性骨髓瘤（RR = 9.5）化疗后观察到显著的ANLL过量。最初接受放射治疗的患者（没有化疗记录）也有明显增加的ANLL风险；45例白血病发生，预期17.9例（RR = 2.5, 95% Cl = 1.8-3.4）。本组子宫癌放疗后发现ANLL过多（RR = 4.0）。肾癌和肾盂癌患者有两倍的白血病风险（所有类型），与治疗无关（RR = 2.2）。
The risk of leukemia associated with the first course of cancer treatment was evaluated in over 440,000 patients diagnosed during 1973-80 (average follow-up = 1.91 yr) from the National Cancer Institute's Surveillance, Epidemiology, and End Results Program. Although the reporting of the first course of therapy probably was incomplete, 34 acute nonlymphocytic leukemias (ANLL) developed compared with 7.6 expected among 70,674 patients known to receive initial chemotherapy [relative risk (RR) = 4.5, 95% confidence interval (Cl) = 3.1-6.3]. Significant ANLL excesses were observed following chemotherapy for breast cancer (RR = 8.1), ovarian cancer (RR = 22.2), and multiple myeloma (RR = 9.5). Patients initially treated with radiation (with no record of chemotherapy) also had a significantly increased ANLL risk; 45 leukemias occurred versus 17.9 expected (RR = 2.5, 95% Cl = 1.8-3.4). In this group, excess ANLL were found following irradiation for uterine corpus cancer (RR = 4.0). Kidney and renal pelvis cancer patients had a twofold leukemia risk (all types) that was unrelated to treatment (RR = 2.2).