Reductions in circulating levels of IL-16, IL-7 and VEGF-A in myalgic encephalomyelitis/chronic fatigue syndrome
Reductions in circulating levels of IL-16, IL-7 and VEGF-A in myalgic encephalomyelitis/chronic fatigue syndrome
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DOI：
10.1016/j.cyto.2015.11.018
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发表时间：
2016-02-01
期刊：
影响因子：
3.8
通讯作者：
Houghton, Michael
中科院分区：
文献类型：
--
作者：
Landi, Abdolamir;Broadhurst, David;Houghton, Michael
最近，各种趋化因子和细胞因子的水平的差异，肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）的患者与对照组相比。此外，长期慢性ME/CFS患者与疾病少于3年的患者之间的分析物谱不同。在目前的研究中，我们测量了34种细胞因子，趋化因子和生长因子在100慢性ME/CFS患者的长期和79个性别和年龄匹配的对照组的血浆水平。我们观察到ME/CFS患者循环中白细胞介素（IL）-16，IL-7和血管内皮生长因子A（VEGF-A）的浓度显著降低。所有三种生物标志物在多变量聚类分析中显著相关。此外，我们发现ME/CFS患者中Fractalkine（CX 3CL 1）和IFN-γ诱导的单核因子（CXCL 9）浓度显著降低，沿着Eotaxin 2（CCL 24）浓度升高。我们的数据概括了来自另一个美国ME/CFS队列的先前数据，其中IL-7的循环水平降低。此外，先前在海湾战争疾病患者的血清中以及来自不同的美国ME/CFS患者队列的脑脊液样品中报道了VEGF-A水平降低。据我们所知，我们是第一个在ME/CFS患者中检测IL-16水平的机构。结合以前的数据，我们的工作表明，IL-7，IL-16和VEGF-A的聚集性减少可能与ME/CFS疾病具有生理相关性。该特征是ME/CFS特异性的，因为慢性感染性和自身免疫性肝病中存在的相同分析物的测量，其中持续疲劳也是主要症状，未能证明相同的变化。未来需要对其他ME/CFS和重叠疾病队列进行进一步研究。(C)2015爱思唯尔有限公司版权所有。
Recently, differences in the levels of various chemokines and cytokines were reported in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) as compared with controls. Moreover, the analyte profile differed between chronic ME/CFS patients of long duration versus patients with disease of less than 3 years. In the current study, we measured the plasma levels of 34 cytokines, chemokines and growth factors in 100 chronic ME/CFS patients of long duration and in 79 gender and age-matched controls. We observed highly significant reductions in the concentration of circulating interleukin (IL)-16, IL-7, and Vascular Endothelial Growth Factor A (VEGF-A) in ME/CFS patients. All three biomarkers were significantly correlated in a multivariate cluster analysis. In addition, we identified significant reductions in the concentrations of fractalkine (CX3CL1) and monokine-induced-by-IFN-gamma (MIG; CXCL9) along with increases in the concentrations of eotaxin 2 (CCL24) in ME/CFS patients. Our data recapitulates previous data from another USA ME/CFS cohort in which circulating levels of IL-7 were reduced. Also, a reduced level of VEGF-A was reported previously in sera of patients with Gulf War Illness as well as in cerebral spinal fluid samples from a different cohort of USA ME/CFS patients. To our knowledge, we are the first to test for levels of IL-16 in ME/CFS patients. In combination with previous data, our work suggests that the clustered reduction of IL-7, IL-16 and VEGF-A may have physiological relevance to ME/CFS disease. This profile is ME/CFS-specific since measurement of the same analytes present in chronic infectious and autoimmune liver diseases, where persistent fatigue is also a major symptom, failed to demonstrate the same changes. Further studies of other ME/CFS and overlapping disease cohorts are warranted in future. (C) 2015 Elsevier Ltd. All rights reserved.