Radiobiology in Cardiovascular Imaging.
Radiobiology in Cardiovascular Imaging.
复制标题
心血管成像中的放射生物学。
DOI：
10.1016/j.jcmg.2016.09.012
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Strauss,HWilliam
中科院分区：
文献类型：
--
作者：
Zanzonico,Pat;Dauer,Lawrence;Strauss,HWilliam
电离辐射在医学中的引入使疾病的诊断和治疗发生了革命性的变化，极大地改善了并继续改善医疗保健的质量。然而，心血管成像和医学成像通常与一系列放射生物学效应相关，包括在极少数情况下由心脏荧光透视引起的中度至重度皮肤损伤。对于与诊断成像相关的剂量范围（对应于10 mSv [1 rem]量级的有效剂量），可能的影响本质上是随机的，主要是理论性的。当然，这些影响中最值得注意的是可能增加癌症风险。目前的审查地址放射生物学相关的心血管成像，特别强调辐射诱发癌症，包括考虑的线性非阈值剂量反应模型和替代模型，如辐射激效。
The introduction of ionizing radiation in medicine revolutionized the diagnosis and treatment of disease and dramatically improved and continues to improve the quality of health care. Cardiovascular imaging and medical imaging in general, however, are associated with a range of radiobiologic effects, including, in rare instances, moderate to severe skin damage resulting from cardiac fluoroscopy. For the dose range associated with diagnostic imaging (corresponding to effective doses on the order of 10 mSv [1 rem]), the possible effects are stochastic in nature and largely theoretical. The most notable of these effects, of course, is the possible increase in cancer risk. The current review addresses radiobiology relevant to cardiovascular imaging, with particular emphasis on radiation induction of cancer, including consideration of the linear nonthreshold dose-response model and of alternative models such as radiation hormesis.