Lewis Base Catalyzed Stereo- and Regioselective Bromocyclization
Lewis Base Catalyzed Stereo- and Regioselective Bromocyclization
复制标题
DOI：
10.1002/tcr.201600088
复制
发表时间：
2017-03-01
期刊：
影响因子：
6.6
通讯作者：
Yeung, Ying-Yeung
中科院分区：
文献类型：
--
作者：
Gieuw, Matthew H.;Ke, Zhihai;Yeung, Ying-Yeung
含氧和含氮杂环化合物被广泛认为是许多天然产物和生物相关分子的关键组分，但通常问题归结为合成它们的方法。烯类底物的卤环化反应是一种很有前途的合成O-和N-杂环化合物的策略，这进一步表明了它们的不对称变体的发展。在过去的几年里，我们的小组一直致力于这一特定领域的不对称亲电卤环化与含硫族元素的分子作为催化剂。在这个帐户中，主要的重点是我们的新型手性催化剂的发展和应用来自反应产物。
Oxygen- and nitrogen-containing heterocyclic compounds are widely recognized as key components in many natural products and biologically relevant molecules, but often the problem comes down to methodologies in synthesizing them. Halocyclization of olefinic substrates is a promising strategy in the construction of O- and N-heterocyclic compounds, which further signifies the development of their asymmetric variants. Over the past years, our group has been devoted to this particular area of asymmetric electrophilic halocyclization with chalcogen-containing molecules as catalysts. In this account, the main focus is on the development of our novel chiral catalysts and applications derived from the reaction products.