Cellulose nanocrystals and cellulose nanofibrils based hydrogels for biomedical applications
Cellulose nanocrystals and cellulose nanofibrils based hydrogels for biomedical applications
复制标题
用于生物医学应用的纤维素纳米晶体和纤维素纳米原纤维基水凝胶
DOI：
10.1016/j.carbpol.2019.01.020
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发表时间：
2019-04-01
影响因子：
11.2
通讯作者：
Li, Bin
中科院分区：
文献类型：
--
作者：
Du, Haishun;Liu, Wei;Li, Bin
从木质纤维生物质中制备纤维素纳米材料为纳米技术中新材料的开发和应用提供了机会。在过去的十年里，纤维素纳米材料水凝胶因其低毒、生物相容性、生物降解性以及优异的机械稳定性而成为生物医学领域中的一种有前途的材料。本文通过对最新研究(特别是近5年来的报道)的分析，总结和讨论了纤维素纳米晶(CNCS)和纤维素纳米纤维(CNFS)水凝胶的制备及其在生物医学中的应用的最新进展。我们首先简要介绍了从木质纤维生物质中分离出来的两种主要类型的纤维素纳米材料：碳纳米管和碳纳米管的制备方法和性能的差异。然后，分别阐述了碳纳米管水凝胶和碳纳米纤维水凝胶的各种制备方法，重点介绍了一些新的制备方法(如3D打印)。此外，还重点介绍了碳纳米管和碳纳米管水凝胶在生物医学方面的应用，包括药物输送、伤口敷料和组织工程支架。最后，总结了碳纳米管和碳纳米纤维水凝胶在生物医学中的应用前景和面临的挑战。这项工作表明，基于碳纳米管和碳纳米纤维的水凝胶在未来的生物医学中具有广泛的应用前景。
The production of cellulose nanomaterials from lignocellulosic biomass opens an opportunity for the development and application of new materials in nanotechnology. Over the last decade, cellulose nanomaterials based hydrogels have emerged as promising materials in the field of biomedical applications due to their low toxicity, biocompatibility, biodegradability, as well as excellent mechanical stability. In this review, recent progress on the preparation of cellulose nanocrystals (CNCs) and cellulose nanofibrils (CNFs) based hydrogels and their biomedical applications is summarized and discussed based on the analyses of the latest studies (especially for the reports in the past five years). We begin with a brief introduction of the differences in preparation methods and properties of two main types of cellulose nanomaterials: CNCs and CNFs isolated from lignocellulosic biomass. Then, various processes for the fabrication of CNCs based hydrogels and CNFs based hydrogels were elaborated, respectively, with the focus on some new methods (e.g. 3D printing). Furthermore, a number of biomedical applications of CNCs and CNFs based hydrogels, including drug delivery, wound dressings and tissue engineering scaffolds were highlighted. Finally, the prospects and ongoing challenges of CNCs and CNFs based hydrogels for biomedical applications were summarized. This work demonstrated that the CNCs and CNFs based hydrogels have great promise in a wide range of biomedical applications in the future.