Cellular affinity of polyamides having various functional groups. I. Platelet adhesion
Cellular affinity of polyamides having various functional groups. I. Platelet adhesion
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具有各种官能团的聚酰胺的细胞亲和力。
DOI：
10.1002/app.1981.070260716
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
K. Kataoka
中科院分区：
文献类型：
--
作者：
N. Ogata;K. Sanui;Hozumi Tanaka;Yoichi Takahashi;Y. Sakurai;T. Akaike;T. Okano;K. Kataoka
合成了具有不同氢键密度、亲水性和含有离子基团的各种聚酰胺，并通过微球柱法根据血小板在聚酰胺上的粘附行为评价了它们的血液相容性。含有阴离子带电基团（例如羧酸盐或磺酸盐基团）的聚酰胺比具有未解离的羧酸盐基团的聚酰胺吸附更少的血小板。具有硫醚基团的聚酰胺比具有醚基团的聚酰胺吸附更少的血小板。刚性哌嗪单元的引入导致血小板粘附增加。
Various polyamides having a different density of hydrogen bonding, of hydrophilic character, and containing ionic groups have been synthesized and their blood compatibilities were evaluated in terms of the adhesion behavior of blood platelets on polyamide by the microsphere column method. Polyamides containing anionically charged groups such as carboxylate or sulfonate groups adsorbed fewer blood platelets than those with undissociated carboxylate groups. Polyamides having thioether groups adsorbed fewer platelets than those having ether groups. Introduction of a rigid piperazine unit caused an increase in platelet adhesion.