Candida sepsis: pathogenesis and principles of treatments.
Candida sepsis: pathogenesis and principles of treatments.
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念珠菌败血症：发病机制和治疗原则。
DOI：
10.1097/00000658-197405000-00024
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发表时间：
1974
影响因子：
9
通讯作者：
J. Cuzzell
中科院分区：
文献类型：
--
作者：
H. Stone;L. Kolb;C. A. Currie;C. Geheber;J. Cuzzell
Following the injection of Candida suspensions (1010-1020/ml) into various levels of canine and primate gastrointestinal tracts, cultures of tissue and blood confirmed that yeast do persorb across an intact intestinal mucosa. In contrast, negative blood and organ cultures after similar Candida inoculation of canine muscle, fat, and granulating pouches seemed to refute the premise that yeast frequently invade from the colonized wound. Only mesothelium was as penetrable to Candida as the bowel. Liver and other tissues functioned somewhat as filters and thereby prevented peripheral venous cultures from being positive with any consistency. Infusions of Candida (102-1014/ml) into the mesenteric veins of dogs and monkeys demonstrated clearance ratios of 10,000 to 1 for liver and 100 to 1 for most other organs and tissues. Results suggest that Candida usually invade from colonized intestine and that arterial or right atrial blood cultures are of greater diagnostic value than the routine venous sample. Treatment always demands that antibiotics be discontinued immediately and that foci responsible for yeast invasion be eradicated by removal of the intravenous and institution of oral antifungal drugs. Application of such conclusions in the prophylaxis of 243 randomized burns and in the management of 58 cases of Candida sepsis are described.I N RECENT YEARS, Candida sepsis has become one of the more common forms of hospital acquired infec-tions. 4" 0" 23'26 Yeast colonization is prone to occur not just in the patient with diabetes mellitus, a condition previously believed almost to be an absolute prerequisite, but also may develop in any individual receiving oral or systemic antibiotics, 30 when steroid, cytotoxic, or immuno-suppressive agents are being administered, 1" 22'3'and coincident to the prolonged use of an intravenous cutdown
