Resident memory T cells in the skin mediate durable immunity to melanoma.
Resident memory T cells in the skin mediate durable immunity to melanoma.
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DOI：
10.1126/sciimmunol.aam6346
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发表时间：
2017-04-14
影响因子：
24.8
通讯作者：
Turk MJ
中科院分区：
文献类型：
--
作者：
Malik BT;Byrne KT;Vella JL;Zhang P;Shabaneh TB;Steinberg SM;Molodtsov AK;Bowers JS;Angeles CV;Paulos CM;Huang YH;Turk MJ
Tissue-resident memory T cells (TRM cells) have been widely characterized in infectious disease settings; however, their role in mediating immunity to cancer remains unknown. Here we report that skin-resident memory T cell responses to melanoma are generated naturally as a result of autoimmune vitiligo. Melanoma antigen-specific TRM cells resided predominantly in melanocyte-depleted hair follicles and were maintained without recirculation or replenishment from the lymphoid compartment. These cells expressed CD103, CD69, and CLA, but lacked PD-1 or LAG-3, and were capable of making IFN-γ. CD103 expression on CD8 T cells was required for establishment of TRM cells in skin, but was dispensable for vitiligo development. Importantly, CD103+ CD8 TRM cells were critical for protection against melanoma re-challenge. This work establishes that CD103-dependent TRM cells play a key role in perpetuating anti-tumor immunity.
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