Antimony (III) Sulfate Catalyzed One-Pot Synthesis of 2,3-Disubstitutedindoles
Antimony (III) Sulfate Catalyzed One-Pot Synthesis of 2,3-Disubstitutedindoles
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DOI：
10.1080/10426500802388250
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发表时间：
2009-01-01
影响因子：
1.3
通讯作者：
Sudhakara, A.
中科院分区：
文献类型：
--
作者：
Srinivasa, A.;Mahadevan, K. M.;Sudhakara, A.
以硫酸锑（III）为催化剂，一锅法合成吲哚。苯肼盐酸盐与酮在甲醇中反应，产率较高。在乙基甲基酮与苯肼的反应中，观察到2，3-二取代吲哚的唯一生成。还描述了使用二氢吡喃一锅法合成吲哚-3-丙醇。使用可重复使用的硫酸锑（III）作为催化剂使得该方法既经济又环保。
A novel one-pot Fischer indole synthesis approach has been developed by using antimony (III) sulfate as the catalyst. Good yields were obtained after reacting phenylhydrazines hydrochlorides and ketones in refluxing methanol. The exclusive formation of 2,3-disubstituted indoles was observed in the reaction of ethyl methyl ketone with phenylhydrazines. One-pot synthesis of indole-3-propanol using dihydropyran has also been described. The use of reusable antimony (III) sulfate as a catalyst makes this method both economically and environmentally friendly.