The mode of decomposition of Angeli's salt (Na2N2O3) and the effects thereon of oxygen, nitrite, superoxide dismutase, and glutathione
The mode of decomposition of Angeli's salt (Na2N2O3) and the effects thereon of oxygen, nitrite, superoxide dismutase, and glutathione
复制标题
DOI：
10.1016/s0891-5849(03)00111-4
复制
发表时间：
2003-06-01
影响因子：
7.4
通讯作者：
Fridovich, I
中科院分区：
文献类型：
--
作者：
Liochev, SI;Fridovich, I
安吉利盐好氧分解的经典观点是，它释放出NO2-+NO-/HNO，然后与O-2反应生成ONOO-。最近提出的一种替代方案设想将电子转移到O-2，然后分解为NO2-+NO。经典的观点现在被观察到的Angeli盐在20%O-2和100%O-2下的分解速率相等所有力地支持。此外，NO2-通过促进反向反应来抑制这种分解，在没有清除NO-/HNO的试剂的情况下更有效。因此，很明显，安吉利盐是NO-/HNO的有用来源，可用于定义的水体系。在这项工作的过程中所做的测量允许近似NO-/HNO与NO2-、O-2、谷胱甘肽或铜、锌超氧化物歧化酶的反应的速率常数。还讨论了NO-/HNO在体内形成的可能性。(C)2003年爱思唯尔公司。
The classical view of the aerobic decomposition of Angeli's salt is that it releases NO2- + NO-/HNO the latter then reacting with O-2 to yield ONOO-. An alternative that has recently been proposed envisions electron transfer to O-2 followed by decomposition to NO2- + NO. The classical view is now strongly supported by the observation that the rates of decomposition of Angeli's salt under 20% O-2 or 100% O-2 were equal. Moreover, NO2-, which inhibits this decomposition by favoring the back reaction, was more effective in the absence of agents that scavenge NO-/HNO. It is thus clear that Angeli's salt is a useful source of NO-/HNO for use in defined aqueous systems. The measurements made in the course of this work allowed approximation of the rate constants for the reactions of NO-/HNO with NO2-, O-2, glutathione, or Cu, Zn superoxide dismutase. The likelihood of the formation of NO-/HNO in vivo is also discussed. (C) 2003 Elsevier Inc.