Round window membrane. Structure function and permeability: A review
Round window membrane. Structure function and permeability: A review
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DOI：
10.1002/(sici)1097-0029(19970201)36:3
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发表时间：
1997-02
影响因子：
2.5
通讯作者：
M. Goycoolea;L. Lundman
中科院分区：
文献类型：
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作者：
M. Goycoolea;L. Lundman
人、猴、猫和啮齿类动物圆窗膜的超微结构显示了三个基本层：外层上皮、中间结缔组织核心和内层上皮。物种间的差异主要是在厚度方面，啮齿动物最薄，人类最厚。形态学证据表明，圆窗的各层参与了物质的吸收和分泌，整个膜可以在耳朵的防御系统中发挥作用。将不同的物质，包括抗生素、局部麻醉剂和示踪剂如阳离子铁蛋白、辣根过氧化物酶和1 μ乳胶微球，放置在中耳侧穿过膜。阳离子铁蛋白和置于外淋巴液中的1微米微球被膜的内上皮细胞掺入。渗透性是选择性的;因素包括大小、浓度、脂溶性、电荷和膜厚度。物质通过圆窗膜是通过不同的途径，其性质似乎由圆窗膜的外上皮决定。显微镜。Res. Tech. 36：201-211，1997.© 1997 Wiley利斯公司
The ultrastructure of the round window membrane of humans, monkeys, felines, and rodents discloses three basic layers: an outer epithelium, a middle core of connective tissue, and an inner epithelium. Interspecies variations are mainly in terms of thickness, being thinnest in rodents and thicker in humans. Morphologic evidence suggests that the layers of the round window participate in absorption and secretion of substances to and from the inner ear, and that the entire membrane could play a role in the defense system of the ear. Different substances, including antibiotics, local anesthetics, and tracers such as cationic ferritin, horseradish peroxidase, and 1 μ latex microspheres, are placed in the middle ear side traverse the membrane. Cationic ferritin and 1 micron microspheres placed in perilymph become incorporated by the inner epithelial cells of the membrane. Permeability is selective; factors include size, concentration, liposolubility, electrical charge, and thickness of the membrane. Passage of substances through the round window membrane is by different pathways, the nature of which is seemingly decided at the outer epithelium of the round window membrane. Microsc. Res. Tech. 36:201–211, 1997. © 1997 Wiley‐Liss, Inc.