Energy expenditure, fat oxidation, and body weight regulation: A study of metabolic adaptation to long-term weight change
Energy expenditure, fat oxidation, and body weight regulation: A study of metabolic adaptation to long-term weight change
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DOI：
10.1210/jc.85.3.1087
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发表时间：
2000-03-01
影响因子：
5.8
通讯作者：
Tataranni, PA
中科院分区：
文献类型：
--
作者：
Weyer, C;Pratley, RE;Tataranni, PA
相对较低的能量消耗率和脂肪氧化率预示着体重增加。反过来，体重增加与能量消耗和脂肪氧化的增加有关，这可能会阻碍体重的进一步变化。在响应实验体重增加诱导的过度喂养，增加能量消耗和脂肪氧化是过度补偿，即大于预测的身体组成的变化。为了确定这种代谢适应是否发生在对自发的长期体重变化的反应中，我们进行了一项纵向研究，其中24小时能量消耗（24-EE）和24小时呼吸商（24-EE）（24-RQ;即脂肪到碳水化合物的氧化）在102名皮马印第安人中重复测量基线和平均随访3.6 ± 2.7年后，在此期间，体重变化范围很大（-21至+28 kg）。我们发现，24-EE和24-RQ对体重变化的反应变化与体重变化量有关，即使在调整身体成分后也是如此（部分r分别为0.23和-0.30;均P < 0.05）。对于15 kg体重增加，24-EE（+244 Gal/天）和24小时脂肪氧化（+152 Gal/天）的增加分别比两种测量值与体重之间的横截面关系预测值高33和53 Gal/天。24-EE和24-RQ的变化在个体之间差异很大。因此，平均而言，自发的长期体重变化伴随着能量消耗和脂肪氧化的小代谢适应。然而，对体重变化的代谢反应在个体之间差异很大。
Relatively low rates of energy expenditure and fat oxidation predict body weight gain. Weight gain, in turn, is associated with increases in energy expenditure and fat oxidation that may oppose further weight change. In response to experimental weight gain induced by overfeeding, increases in energy expenditure and fat oxidation are overcompensatory, i.e. greater than predicted for the change in body composition. To determine whether such metabolic adaptation occurs in response to spontaneous long term weight change, we conducted a longitudinal study in which 24-h energy expenditure (24-EE) and 24-h respiratory quotient (24-RQ; i.e. fat to carbohydrate oxidation) were repeatedly measured in 102 Pima Indians at baseline and after a mean follow-up of 3.6 +/- 2.7 yr, during which changes in body weight varied widely (-21 to +28 kg). We found that changes in 24-EE and 24-RQ in response to weight change were related to the amount of weight change, even after adjustment for body composition (partial r = 0.23 and -0.30, respectively; both P < 0.05). For a 15-kg weight gain, the increases in 24-EE (+244 Gal/day) and 24-h fat oxidation (+152 Gal/day) were 33 and 53 Gal/day greater than predicted from the cross-sectional relationship between both measures and body weight. Changes in 24-EE and 24-RQ varied substantially among individuals. Thus, on the average, spontaneous long term weight changes are accompanied by small metabolic adaptations in both energy expenditure and fat oxidation. The metabolic responses to weight changes are highly variable among individuals, however.