Morphology and Properties of Pericytes
Morphology and Properties of Pericytes
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DOI：
10.1007/978-1-60761-938-3_2
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发表时间：
2011-01-01
期刊：
影响因子：
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通讯作者：
Cleary, Kristen
中科院分区：
文献类型：
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作者：
Dore-Duffy, Paula;Cleary, Kristen
周细胞于1873年由法国科学家夏尔 - 玛丽·本杰明·鲁热（Charles - Marie Benjamin Rouget）描述，最初被称为鲁热细胞。若干年后，由于其在解剖学位置上位于内皮细胞（EC）的管腔外和实质细胞的管腔内，鲁热细胞被重新命名。在大脑中，周细胞位于毛细血管前小动脉、毛细血管和毛细血管后小静脉中。它们沉积基膜成分，并完全被这种血管成分所包围。周细胞是血脑屏障（BBB）的重要细胞组成部分，并且与神经血管单元的其他细胞（如内皮细胞、星形胶质细胞和神经元）积极交流。周细胞是局部调节细胞，对维持内稳态和止血很重要，并且是成体多能干细胞的一个来源。对这种有趣细胞所起作用的进一步了解可能会为神经血管疾病带来新的靶向治疗方法。
Pericytes were described in 1873 by the French scientist Charles-Marie Benjamin Rouget and were originally called Rouget cells. The Rouget cell was renamed some years later due to its anatomical location abluminal to the endothelial cell (EC) and luminal to parenchymal cells. In the brain, pericytes are located in precapillary arterioles, capillaries and postcapillary venules. They deposit elements of the basal lamina and are totally surrounded by this vascular component. Pericytes are important cellular constituents of the blood brain barrier (BBB) and actively communicate with other cells of the neurovascular unit such as ECs, astrocytes, and neurons. Pericytes are local regulatory cells that are important for the maintenance of homeostasis and hemostasis, and are a source of adult pluripotent stem cells. Further understanding of the role played by this intriguing cell may lead to novel targeted therapies for neurovascular diseases.