The role of inflammatory pathways in cancer-associated cachexia and radiation resistance.
The role of inflammatory pathways in cancer-associated cachexia and radiation resistance.
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DOI：
10.1158/1541-7786.mcr-13-0189
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发表时间：
2013-09
期刊：
影响因子：
--
通讯作者：
Pandita TK
中科院分区：
文献类型：
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作者：
Laine A;Iyengar P;Pandita TK
失调的炎症反应在包括癌症在内的许多慢性疾病中都很重要。癌症的疾病进展依赖于肿瘤和宿主微环境之间复杂的相互作用，包括炎症反应，因为肿瘤和微环境成分都可以产生作用于多个靶点的细胞因子，在这些靶点上促进复杂的级联生物反应。癌症相关恶病质（CAC）患者遭受骨骼肌和脂肪组织的严重损失，因此，许多形式的治疗干预被排除在外，包括放射治疗。与促进病毒质反应有关的细胞因子也在抗辐射中发挥作用。细胞因子水平的主要变化部分是由于转录调控的改变，可能是由于表观遗传修饰。在这里，我们总结了炎症途径在CAC中的作用，并讨论了恶病质诱导与辐射抵抗之间的潜在联系。
Dysregulated inflammatory responses are important in a multitude of chronic ailments, including cancer. Disease progression in cancer is dependent on the complex interaction between the tumor and the host microenvironment, including inflammatory responses, as both the tumor and microenvironment components can produce cytokines that act on multiple target sites where they promote a complex cascade of biologic responses. Patients with cancer-associated cachexia (CAC) suffer from a dramatic loss of skeletal muscle and adipose tissue and are, therefore, precluded from many forms of therapeutic interventions, including radiotherapy. The cytokines that have been linked to the promotion of the cachectic response also play a role in radiation resistance. The major changes at the cytokine level are in part due to transcriptional regulatory alterations possibly due to epigenetic modifications. Here, we summarize the role of inflammatory pathways in CAC and discuss the potential link between cachexia induction and radiation resistance.