EPIDEMIOLOGIC STUDIES OF STREPTOCOCCUS-PNEUMONIAE IN INFANTS - THE EFFECTS OF SEASON AND AGE ON PNEUMOCOCCAL ACQUISITION AND CARRIAGE IN THE 1ST 24 MONTHS OF LIFE
EPIDEMIOLOGIC STUDIES OF STREPTOCOCCUS-PNEUMONIAE IN INFANTS - THE EFFECTS OF SEASON AND AGE ON PNEUMOCOCCAL ACQUISITION AND CARRIAGE IN THE 1ST 24 MONTHS OF LIFE
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DOI：
10.1093/oxfordjournals.aje.a113452
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发表时间：
1982-01-01
影响因子：
5
通讯作者：
DILLON, HC
中科院分区：
文献类型：
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作者：
GRAY, BM;TURNER, ME;DILLON, HC
在1974年11月至1975年12月阿拉巴马州伯明翰出生时登记的婴儿中肺炎球菌携带和感染的自然历史的研究中，观察到感染和携带肺炎球菌的模式似乎受到年龄和一年中的季节的影响。为了更准确地描述这些影响，使用原始数据建立了前24个月肺炎球菌的获得率、携带率和携带持续时间的多元回归模型。生活的一部分。收购速度具有很强的季节性，冬季高峰期明显，夏季低点。运输率的季节性波动要小得多。随着年龄的增长，习得率增加，而运输持续时间减少；这些综合作用体现在运输率上，到9个月龄时，运载率急剧增加，然后趋于平稳。虽然年龄和季节在采购率和运输率的变化中所占的比例相对较小，但模型被发现非常符合数据。有可能以精确的方式分析数据，确认先前的观察结果，并将它们与过去50年来其他调查人员的工作联系起来。
In a study of the natural history of pneumococcal carriage and infection in infants enrolled at birth in Birmingham, Alabama [USA] from Nov. 1974 to Dec. 1975, patterns of acquisition and carriage that appeared to be influenced by age and the season of the year were observed. To describe more precisely these effects, the original data were used to construct multiple regression models for acquisition, carriage rates and duration of carriage of pneumococci during the first 24 mo. of life. The acquisition rate was strongly seasonal, with a marked winter peak and summer low. Seasonal fluctuations in the carriage rate were much less pronounced. The acquisition rate increased with age, while the duration of carriage decreased; these combined effects were reflected in the carriage rate, which increased sharply up to the age of 9 mo., then leveled off. While age and season accounted for a relatively small part of the variation in acquisition and carriage rates, the models were found to fit the data very well. It was possible to analyze the data in a precise fashion, confirm earlier observations and relate them to the work of other investigators over the past 50 yr.