Characteristics of developmentally early alcohol use disorder symptom reports: A prospective-longitudinal community study
Characteristics of developmentally early alcohol use disorder symptom reports: A prospective-longitudinal community study
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DOI：
10.1016/j.drugalcdep.2012.12.024
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发表时间：
2013-08-01
影响因子：
4.2
通讯作者：
Beesdo-Baum, K.
中科院分区：
文献类型：
--
作者：
Behrendt, S.;Buehringer, G.;Beesdo-Baum, K.
背景：关于DSM-IV酒精使用障碍(酒精滥用和依赖；AUD)症状的前瞻性流行病学信息很少，这种症状可能是AUD早期或青春期和成年期早期的典型症状。目的：在随后的三个评估波中横断面调查AUDS的患病率、症状计数、相关饮酒模式、DSM-IV酒精依赖(AD)的阳性预测值(PPV)以及AUDS随时间的稳定性。方法：N=2039名社区受试者(基线年龄14-24岁)参加了长达10年的基线和两次随访评估(S)。用DSM-IV/M-CIDI对DSM-IV-AUDS、DSM-IV-AUD和渴求进行测评。结果：在整个测评波中，耐受性和时间过长最多，角色义务和退缩最少。大多数患有DSM-IV-AUDS的受试者只报告一种症状(47.2-55.1%)。DSM-IV-AD的PPV仅在活动、问题、戒断和期望控制方面超过70%；在耐受性和危险用途方面PPV最低。对于大多数AUDS，AUDS报告与未报告的相比与饮酒频率和饮酒量的增加有关。在四年和十年的随访中，基线AUDS的稳定性不超过任何症状的36.4%。结论：青春期和成年期早期报道的AUDS最常见/最不常见的总体模式与老年人的研究结果相似，并不提示具有发育特异性的症状模式。中等的AUDS稳定性和相当大的缓解率表明，对于相当一部分受试者来说，这个年龄段的AUDS是一过性的。然而，与消费增加的关联表明，在预防和干预中，需要认真对待AUDS的早期报告。(C)2013爱思唯尔爱尔兰有限公司。保留所有权利。
Background: There is little prospective-epidemiological information on symptoms of DSM-IV-alcohol use disorder (alcohol abuse and dependence; AUD) that may be typical for early AUD stages or the developmental periods of adolescence and early adulthood. Aims: To investigate AUD symptoms (AUDS) cross-sectionally at three subsequent assessment waves regarding prevalence rates, symptom counts, associated drinking patterns, positive predictive values (PPV) for DSM-IV-alcohol dependence (AD), and AUDS stability over time.Methods: N=2039 community subjects (baseline age 14-24 years) participated in a baseline and two follow-up assessment(s) over up to ten years. DSM-IV-AUDS, DSM-IV-AUD and craving were assessed with the DSM-IV/M-CIDI.Results: Over the assessment waves, tolerance and much time were most and role obligations and withdrawal least frequent. Most subjects with DSM-IV-AUDS reported only one symptom (47.2-55.1%). PPV for DSM-IV-AD only exceeded 70% for activities, problem, withdrawal, and desired control; PPV were lowest for tolerance and hazardous use. For most AUDS, AUDS report compared to non-report was associated with elevated drinking frequency and amounts. Stability of baseline AUDS at four-year and ten-year follow-up did not exceed 36.4% for any symptom.Conclusions: The overall pattern of most/least frequent AUDS reported in adolescence and early adulthood resembles findings in older adults and does not suggest a developmentally specific symptom pattern. Moderate AUDS-stability and considerable remission rates indicate that AUDS in this age group are transient for a considerable proportion of subjects. However, the associations with elevated consumption indicate that AUDS reports early in life need to be taken seriously in prevention and intervention. (C) 2013 Elsevier Ireland Ltd. All rights reserved.