Oxytocin and vasopressin receptor distributions in a solitary and a social species of tuco-tuco (Ctenomys haigi and Ctenomys sociabilis)
Oxytocin and vasopressin receptor distributions in a solitary and a social species of tuco-tuco (Ctenomys haigi and Ctenomys sociabilis)
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DOI：
10.1002/cne.21638
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发表时间：
2008-04-20
影响因子：
2.5
通讯作者：
Francis, Darlene D.
中科院分区：
文献类型：
--
作者：
Beery, Annaliese K.;Lacey, Eileen A.;Francis, Darlene D.
神经肽催产素和加压素及其受体与哺乳动物社会行为的要素有关，例如对配偶和后代的依恋，但它们在调解其他类型的社会关系中的潜在作用仍然很大程度上未知。我们进行受体放射自显影，以评估是否前脑催产素受体（OTR）或加压素V1a受体（V1aR）的分布与社会结构的两个密切相关的和生态相似的物种，南美啮齿动物，殖民tuco tuco（Ctenomys sociabilis）和巴塔哥尼亚tuco tuco（Ctenomys haigi）。长期的田间研究表明，C。haigi是孤生的，而C. sociabilis是社会性的，提供了一种以女性为基础的群体生活模式。我们的分析表明，这些物种之间的OTR和V1aR分布的显着差异。例如，只有C.群居猴在梨状皮质和丘脑中有OTR结合，在嗅球中有V1aR结合。与此相反，C. haigi在整个外侧隔和海马中显示出显著更高水平的OTR结合。更普遍地说，集体生活的C。sociabilis表现出一种模式的核腹侧苍白球OTR和V1aR结合不同，与形成异性配对债券在microtine啮齿动物。在C. sociabilis与C.社交焦虑的减少可以促进社交能力。外侧隔的低OTR结合也可能是生活在C.社交未来的研究将扩大这些分析，探讨种间差异ctenomyid受体结合模式的系统发育背景下。
The neuropeptides oxytocin and vasopressin and their receptors have been implicated in elements of mammalian social behavior such as attachment to mates and offspring, but their potential role in mediating other types of social relationships remains largely unknown. We performed receptor autoradiography to assess whether forebrain oxytocin receptor (OTR) or vasopressin V1a receptor (V1aR) distributions differed with social structure in two closely related and ecologically similar species of South American rodents, the colonial tuco-tuco (Ctenomys sociabilis) and the Patagonian tuco-tuco (Ctenomys haigi). Long-term field studies have revealed that C. haigi is solitary, whereas C. sociabilis is social and provides a model of female-based group living. Our analyses revealed marked differences in OTR and V1aR distributions between these species. For example, only C. sociabilis had OTR binding in the piriform cortex and thalamus and V1aR binding in the olfactory bulbs. In contrast, C. haigi exhibited dramatically higher levels of OTR binding throughout the lateral septum and hippocampus. More generally, the group-living C. sociabilis exhibited a pattern of nucleus accumbens OTR and ventral pallidum V1aR binding different from that associated with the formation of opposite-sex pair bonds in microtine rodents. Higher binding in the central nucleus of the amygdala of C. sociabilis was consistent with the hypothesis that formation of social groups in C. sociabilis may be facilitated by reduced social anxiety. Low OTR binding in the lateral septum might also be a permissive factor for group living in C. sociabilis. Future studies will expand on these analyses to explore interspecific differences in ctenomyid receptor binding patterns in a phylogenetic context.