Long-Term Persistence of Hormonal Adaptations to Weight Loss
Long-Term Persistence of Hormonal Adaptations to Weight Loss
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DOI：
10.1056/nejmoa1105816
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发表时间：
2011-10-27
影响因子：
158.5
通讯作者：
Proietto, Joseph
中科院分区：
文献类型：
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作者：
Sumithran, Priya;Prendergast, Luke A.;Proietto, Joseph
背景减肥后，参与体重稳态调节的几种外周激素的循环水平发生变化。这些变化是短暂的还是随着时间的推移持续存在，对于理解饮食诱导减肥后体重反弹率高的原因可能很重要。方法我们招募了 50 名没有糖尿病的超重或肥胖患者，参加为期 10 周的减肥计划，其中规定了极低能量饮食。在基线（减肥前）、第 10 周（计划完成后）和第 62 周，我们检查了瘦素、生长素释放肽、肽 YY、抑胃多肽、胰高血糖素样肽 1、胰岛淀粉样多肽、胰多肽、胆囊收缩素和胰岛素的循环水平以及主观食欲评分。 结果 体重减轻（平均值 [+/- SE]，13.5 +/- 0.5 kg）导致瘦素、肽YY、胆囊收缩素、胰岛素（P
BACKGROUNDAfter weight loss, changes in the circulating levels of several peripheral hormones involved in the homeostatic regulation of body weight occur. Whether these changes are transient or persist over time may be important for an understanding of the reasons behind the high rate of weight regain after diet-induced weight loss.METHODSWe enrolled 50 overweight or obese patients without diabetes in a 10-week weight-loss program for which a very-low-energy diet was prescribed. At baseline (before weight loss), at 10 weeks (after program completion), and at 62 weeks, we examined circulating levels of leptin, ghrelin, peptide YY, gastric inhibitory polypeptide, glucagon-like peptide 1, amylin, pancreatic polypeptide, cholecystokinin, and insulin and subjective ratings of appetite.RESULTSWeight loss (mean [+/- SE], 13.5 +/- 0.5 kg) led to significant reductions in levels of leptin, peptide YY, cholecystokinin, insulin (P