Suppressive Effect of Antiulcer Agents on Granulocytes—A Role for Granulocytes in Gastric Ulcer Formation
Suppressive Effect of Antiulcer Agents on Granulocytes—A Role for Granulocytes in Gastric Ulcer Formation
复制标题
抗溃疡药对粒细胞的抑制作用——粒细胞在胃溃疡形成中的作用
DOI：
10.1023/a:1005526126694
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发表时间：
2000
影响因子：
3.1
通讯作者：
T. Abo
中科院分区：
文献类型：
--
作者：
T. Kawamura;C. Miyaji;S. Toyabe;Minoru Fukuda;Hisami Watanabe;T. Abo
许多临床医生认为H2受体阻滞剂和质子泵抑制剂通过其抗酸功能改善胃溃疡。我们研究了这些抗酸剂对粒细胞的影响。胃溃疡患者给予H2-阻断剂或质子泵抑制剂一周，并检查粒细胞数量和超氧化物产生。为了确定粒细胞的运输，小鼠暴露于约束应激24 hr.H2-阻滞剂减少了粒细胞的数量，而质子泵抑制剂抑制了人类和小鼠的超氧化物的产生。H2受体阻滞剂和质子泵抑制剂在治疗胃溃疡中的主要功能似乎是它们对粒细胞的抑制作用。在这种情况下，压力加速粒细胞从骨髓到胃粘膜的运输。如果我们证实粒细胞在胃溃疡形成中的作用，就填补了酸性胃蛋白酶理论和幽门螺杆菌理论之间的空白。
Many clinicians have believed that H2-blockers and proton pump inhibitors ameliorate gastric ulcers via their antacid function. We examined the effects of these antacids on granulocytes. Gastric ulcer patients were administered an H2-blocker or proton pump inhibitor for a week and the number of granulocytes and the superoxide production were examined. To determine the trafficking of granulocytes, mice were exposed to restraint stress for 24 hr. The H2-blocker decreased the number of granulocytes, while the proton pump inhibitor suppressed their superoxide production in humans and mice. The major function of H2-blockers and proton pump inhibitors in curing gastric ulcers seems to be their suppressive effects on granulocytes. In this case, stress accelerates the trafficking of granulocytes from the bone marrow to the gastric mucosa. If we demonstrate a role for granulocytes in gastric ulcer formation, an gap in the acid–pepsin theory and theHelicobacter pyloritheory is filled in.