New imidazole alkaloids from the Indonesian sponge Leucetta chagosensis
New imidazole alkaloids from the Indonesian sponge Leucetta chagosensis
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DOI：
10.1021/np0305223
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发表时间：
2004-05-01
影响因子：
5.1
通讯作者：
Proksch, P
中科院分区：
文献类型：
--
作者：
Hassan, W;Edrada, R;Proksch, P
对印度尼西亚采集的海绵 Leucetta chagosensis 进行的化学研究除了已知化合物 naamine A (1) 之外，还发现了五种新的咪唑生物碱：naamine F (2)、naamine G (3)、kealiinine A (6)、kealiinine B (7) 和 kealiinine C (8)。 Naamine G (3) 对植物病原真菌 Cladosporium herbarum 表现出强大的抗真菌活性，并且对小鼠淋巴瘤 (L5178Y) 和人宫颈癌 (HeLa) 细胞系也表现出轻微的细胞毒性。在丰年虾测定中，kealiinine A (6) 比 naamine G (3) 活性更高。通过一维和二维核磁共振和质谱数据明确确定了新化合物的结构。
Chemical investigation of the sponge Leucetta chagosensis collected in Indonesia afforded five new imidazole alkaloids, naamine F (2), naamine G (3), kealiinine A (6), kealiinine B (7), and kealiinine C (8), in addition to the known compound naamine A (1). Naamine G (3) exhibited strong antifungal activity against the phytopathogenic fungus Cladosporium herbarum and also showed mild cytotoxicity against mouse lymphoma (L5178Y) and human cervix carcinoma (HeLa) cell lines. In the brine shrimp assay, kealiinine A (6) was more active than naamine G (3). The structures of the new compounds were unambiguously established by 1D and 2D NMR and MS data.