Blood-Oxygen Level Dependent MRI Measures of Cerebrovascular Reactivity Using a Controlled Respiratory Challenge: Reproducibility and Gender Differences
Blood-Oxygen Level Dependent MRI Measures of Cerebrovascular Reactivity Using a Controlled Respiratory Challenge: Reproducibility and Gender Differences
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DOI：
10.1002/jmri.22044
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发表时间：
2010-02-01
影响因子：
4.4
通讯作者：
Crawley, Adrian P.
中科院分区：
文献类型：
--
作者：
Kassner, Andrea;Winter, Jeff D.;Crawley, Adrian P.
目的：评价使用血氧水平依赖性（BOLD）对控制潮气末二氧化碳分压变化（PETCO（2））的反应获得的脑血管反应性（CVR）测量结果的重现性和性别差异。材料和方法：我们获得了伦理批准，对19名健康志愿者进行了成像（10名男性，9名女性）在1.5特斯拉M MRI扫描仪上使用相同的程序在两个单独的日子进行两次。CVR图像是通过在由顺序气体输送系统诱导的PETCO（2）的受控变化期间收集BOLD MRI数据来生成的。使用组内相关系数（ICC），我们证明了在灰质（GM）中出色的日内CVR测量结果。（ICC = 0.92）和白色物质（WM）（ICC = 0.88）区域，GM（ICC = 0.81）的日间重现性极佳，WM（ICC = 0.66）的日间重现性良好。GM和Vim的CVR值在男性和女性之间存在显著差异。男性表现出22 +/- 2%的更大的CVR在GM和17 +/- 2%的更大的CVR在WM相比femines.Conclusion：我们的研究结果表明，BOLD MRI CVR测量的可靠性使用控制脑血管的挑战。使用这种技术，我们还发现，与女性相比，男性对CO（2）的BOLD反应显着增加。
Purpose: To evaluate the reproducibility and gender differences in cerebrovascular reactivity (CVR) measurements obtained using the blood-oxygen level dependent (BOLD) response to controlled changes in end-tidal partial pressure of carbon dioxide (PETCO(2))Materials and Methods: We obtained ethical approval to image 19 healthy volunteers (10 men, 9 women) on a 1.5 Tesla M MRI scanner twice on two separate days using identical procedures. CVR images were generated by collecting BOLD MRI data during controlled changes in PETCO(2) induced by a sequential gas delivery system.Results: Using the intraclass correlation coefficient (ICC), we demonstrated excellent within-day CVR measures in gray matter (GM) (ICC = 0.92) and white matter (WM) (ICC = 0.88) regions, excellent between-day reproducibility in GM (ICC = 0.81), and good between-day reproducibility in the WM (ICC = 0.66). CVR values between men and women were significantly different in the GM and VIM. Men exhibited a 22 +/- 2% greater CVR in GM and a 17 +/- 2% greater CVR in WM compared with females.Conclusion: Our results demonstrate the reliability of BOLD MRI CVR measurements obtained using a controlled cerebrovascular challenge. Using this technique, we also revealed significantly increased BOLD response to CO(2) in males compared with females.