Danofloxacin (Advocinâ„¢) reduces the spread of contagious bovine pleuropneumonia to healthy in-contact cattlee
Danofloxacin (Advocinâ„¢) reduces the spread of contagious bovine pleuropneumonia to healthy in-contact cattlee
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DOI：
10.1016/j.rvsc.2006.02.005
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发表时间：
2006-12-01
影响因子：
2.4
通讯作者：
Nicholas, Robin A. J.
中科院分区：
文献类型：
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作者：
Huebschle, Otto J. B.;Ayling, Roger D.;Nicholas, Robin A. J.
传染性牛胸膜肺炎 (CBPP)，由丝状支原体亚种引起。蕈状菌 SC (MmmSC) 是撒哈拉以南非洲地区牛最重要的疾病之一。 T1/44活疫苗通常用于控制它，但只能产生短暂的保护并引起不良反应。本研究评估了达氟沙星（2.5% Advocin (TM)，辉瑞有限公司）治疗自然感染牛和预防 CBPP 向接触牛传播的功效。从自然爆发中捕获的成年牛被分为两组，每组 10 只，并饲养在相距 50 m 围场的研究农场中。一组在第 0、1 和 2 天用 2.5 mg/kg 达氟沙星治疗；另一组接受盐水治疗。第 2 天，将 10 头不含 CBPP、血清阴性的牛与两组中的每一组接触。对所有牛进行为期 3.5 个月的监测。与未治疗的受 CBPP 影响的牛相比，用达氟沙星治疗的 CBPP 影响的牛的临床改善没有差异，每组中约有一半的牛因 CBPP 或在尸检时显示 CBPP 病变而被退出。两组的临床评分也相似。然而，与与未经治疗的受 CBPP 影响的牛接触的牛相比，与达氟沙星治疗的受 CBPP 影响的牛接触的牛表现出明显较少的病变、较低的死亡率和较少的动物呈血清阳性 (P < 0.02)，并且临床评分降低 (P < 0.001)。 MmmSC 也从与治疗组保持接触的较少对照中分离出来。这些发现可能对非洲 CBPP 的控制产生重要影响。 Crown 版权所有 (c) 2006 由 Elsevier Ltd 出版。保留所有权利。
Contagious bovine pleuropneumonia (CBPP), caused by Mycoplasma mycoides subsp. mycoides SC (MmmSC), is one of the most important diseases of cattle in Sub-Saharan Africa. The live T1/44 vaccine is normally used for its control but produces only transient protection and gives rise to adverse reactions. The present study evaluated the efficacy of danofloxacin (2.5% Advocin (TM), Pfizer Ltd.) for the treatment of naturally infected cattle and in the prevention of CBPP transmission to in-contact cattle. Adult cattle, taken from a natural outbreak, were placed into two groups of 10 animals and kept on a research farm in paddocks 50 m apart. One group was treated with 2.5 mg/kg danofloxacin on days 0, 1 and 2; the other group were saline treated. On day 2, 10 CBPP-free, seronegative cattle were placed in contact with each of the two groups. All cattle were monitored for 3.5 months. No differences were seen in clinical improvement of the CBPP-affected cattle treated with danofloxacin compared with the untreated CBPP-affected cattle with approximately half of each group being withdrawn because of CBPP or showing CBPP lesions at post mortem examination. Clinical scores of the two groups were also similar. However cattle kept in contact with the danofloxacin-treated CBPP-affected animals showed significantly fewer lesions, less mortality and fewer animals were seropositive (P < 0.02) and had reduced clinical scores (P < 0.001) compared to cattle kept in contact with untreated CBPP-affected cattle. MmmSC was also isolated from fewer contact controls kept with the treated group. These findings could have important implications for the control of CBPP in Africa. Crown Copyright (c) 2006 Published by Elsevier Ltd. All rights reserved.