Molecular Mechanisms of Vascular Calcification in Chronic Kidney Disease: The Link between Bone and the Vasculature.
Molecular Mechanisms of Vascular Calcification in Chronic Kidney Disease: The Link between Bone and the Vasculature.
复制标题
DOI：
10.1007/s11914-015-0270-3
复制
发表时间：
2015-08
影响因子：
4.3
通讯作者：
Chen, Yabing
中科院分区：
文献类型：
--
作者：
Byon, Chang Hyun;Chen, Yabing
血管钙化在慢性肾病（CKD）患者中非常普遍，并增加了这些患者的死亡率。钙和磷酸盐稳态受损、氧化应激增加和钙化抑制剂丢失与CKD中的血管钙化有关。此外，受损的骨骼可能扰乱血清钙/磷酸盐及其关键调节因子甲状旁腺激素，从而导致CKD中血管钙化增加。CKD的治疗方法，如磷酸盐结合剂和双膦酸盐，已被证明可以改善骨丢失以及血管钙化。CKD血管钙化的确切机制以及骨代谢对血管钙化的作用尚未阐明。本文综述了系统性尿毒症因素和骨代谢受损在CKD血管钙化发病机制中的作用。强调了关键成骨转录因子Runx相关转录因子2（Runx 2）的调节和Runx 2依赖性核因子κ B配体受体激活因子（RANKL）在CKD血管钙化中的新兴作用。
Vascular calcification is highly prevalent in patients with chronic kidney disease (CKD) and increases mortality in those patients. Impaired calcium and phosphate homeostasis, increased oxidative stress, and loss of calcification inhibitors have been linked to vascular calcification in CKD. Additionally, impaired bone may perturb serum calcium/phosphate and their key regulator, parathyroid hormone, thus contributing to increased vascular calcification in CKD. Therapeutic approaches for CKD, such as phosphate binders and bisphosphonates, have been shown to ameliorate bone loss as well as vascular calcification. The precise mechanisms responsible for vascular calcification in CKD and the contribution of bone metabolism to vascular calcification have not been elucidated. This review discusses the role of systemic uremic factors and impaired bone metabolism in the pathogenesis of vascular calcification in CKD. The regulation of the key osteogenic transcription factor Runt-related transcription factor 2 (Runx2) and the emerging role of Runx2-dependent receptor activator of nuclear factor kappa-B ligand (RANKL) in vascular calcification of CKD are emphasized.
登录
查看更多内容
影响因子：
24
作者：
Elmariah, Sammy;Delaney, Joseph A. C.;O'Brien, Kevin D.;Budoff, Matthew J.;Vogel-Claussen, Jens;Fuster, Valentin;Kronmal, Richard A.;Halperin, Jonathan L.
通讯作者：
Halperin, Jonathan L.
影响因子：
4.8
作者：
Heiss, A;DuChesne, A;Jahnen-Dechent, W
通讯作者：
Jahnen-Dechent, W
影响因子：
4.8
作者：
Byon, Chang Hyun;Javed, Amjad;Chen, Yabing
通讯作者：
Chen, Yabing
影响因子：
19.6
作者：
Chen, N. X.;Duan, D.;Moe, S. M.
通讯作者：
Moe, S. M.
影响因子：
13.2
作者：
Ishimura, E;Taniwaki, H;Nishizawa, Y
通讯作者：
Nishizawa, Y