Post-translational modification of retinoic acid receptor alpha and its roles in tumor cell differentiation
Post-translational modification of retinoic acid receptor alpha and its roles in tumor cell differentiation
复制标题
DOI：
10.1016/j.bcp.2019.113696
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Meidan Ying
中科院分区：
文献类型：
--
作者：
Aixiao Xu;Ning Zhang;Ji Cao;Hong Zhu;Bo Yang;Qiaojun He;Meidan Ying
Retinoic acid (RA) is a well-known differentiation inducer that exerts its effects by binding to nuclear RA receptors. Retinoic acid receptor α (RARα), as an important nuclear RA receptor, is activated upon RA binding and facilitates the transcription of target genes related to differentiation, which ultimately initiates cell differentiation. Previous studies have found that the transcriptional activity of RARα is regulated by various post-translational modifications, which influence its DNA binding efficiency, transactivation ability and even lead to degradation. Post-translational modifications of RARα, as a consequence, play an important role in the RA-induced differentiation process. Therefore, in this review, we focus on recent advances in the understanding of how these modifications affect the activity of RARα as well as strategies to increase the differentiation effect of RA treatment in cancer cells based on RARα modifications, which may promote the development of novel effective differentiation therapies for cancer treatment.
